Biological and environmental predictors of heterogeneity in neurocognitive ageing Evidence from Betula and other longitudinal studies

被引：79

作者：

Nyberg, Lars ^{[1
,2
,3
]}

Boraxbekk, Carl-Johan ^{[1
,2
,4
,5
]}

Sorman, Daniel Eriksson ^{[6
]}

Hansson, Patrik ^{[7
]}

Herlitz, Agneta ^{[8
]}

Kauppi, Karolina ^{[3
,9
]}

Ljungberg, Jessica K. ^{[6
]}

Lovheim, Hugo ^{[10
,11
]}

Lundquist, Anders ^{[2
,12
]}

Adolfsson, Annelie Nordin ^{[13
]}

Oudin, Anna ^{[14
,16
]}

Pudas, Sara ^{[2
,3
]}

Ronnlund, Michael ^{[7
]}

Stiernstedt, Mikael ^{[2
,3
]}

Sundstrom, Anna ^{[7
,15
]}

Adolfsson, Rolf ^{[13
]}

机构：

[1] Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden

[2] Umea Univ, Umea Ctr Funct Brain Imaging UFBI, S-90187 Umea, Sweden

[3] Umea Univ, Dept Integrat Med Biol, S-90187 Umea, Sweden

[4] Univ Copenhagen, Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance DRCMR, Copenhagen, Denmark

[5] Univ Copenhagen, Hosp Bispebjerg, Inst Sports Med Copenhagen ISMC, Copenhagen, Denmark

[6] Lulea Univ Technol, Dept Human Work Sci, SE-97187 Lulea, Sweden

[7] Umea Univ, Dept Psychol, S-90187 Umea, Sweden

[8] Karolinska Inst, Div Psychol, Dept Clin Neurosci, S-17177 Stockholm, Sweden

[9] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[10] Umea Univ, Geriatr Med, Dept Community Med & Rehabil, Umea, Sweden

[11] Umea Univ, Wallenberg Ctr Mol Med WCMM, Umea, Sweden

[12] Umea Univ, USBE, Dept Stat, S-90187 Umea, Sweden

[13] Umea Univ, Dept Clin Sci, S-90187 Umea, Sweden

[14] Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden

[15] Umea Univ, Ctr Demog & Ageing Res CEDAR, S-90187 Umea, Sweden

[16] Lund Univ, Occupat & Environm Med, Environm Soc & Hlth, Lund, Sweden

来源：

AGEING RESEARCH REVIEWS | 2020年 / 64卷

基金：

瑞典研究理事会; 欧盟地平线“2020”;

关键词：

ageing; memory; longitudinal; brain; genetics; lifestyle; brain maintenance; cognitive reserve; TRAUMATIC BRAIN-INJURY; CLINICAL DIAGNOSTIC-CRITERIA; RESTING-STATE CONNECTIVITY; GENERAL COGNITIVE FUNCTION; ADULT AGE-DIFFERENCES; HERPES-SIMPLEX-VIRUS; MILD HEAD-INJURY; EPISODIC-MEMORY; SEX-DIFFERENCES; AIR-POLLUTION;

D O I：

10.1016/j.arr.2020.101184

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.

引用

页数：23

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