Update on Medullary Thyroid Cancer

被引：27

作者：

Hu, Mimi I. ^{[1
]}

Ying, Anita K. ^{[1
]}

Jimenez, Camilo ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 02期

关键词：

Medullary thyroid carcinoma; MEN type 2; Pathophysiology; Diagnosis; Treatment; GROWTH-FACTOR RECEPTOR; POSITRON-EMISSION-TOMOGRAPHY; FINE-NEEDLE-ASPIRATION; RET PROTOONCOGENE MUTATIONS; DENDRITIC CELL VACCINATION; ANTIGEN DOUBLING-TIMES; PHASE-II TRIAL; PROGNOSTIC-FACTORS; TYROSINE KINASE; SOMATIC MUTATIONS;

D O I：

10.1016/j.ecl.2014.02.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Medullary thyroid carcinoma (MTC) is a rare type of thyroid cancer, demonstrating variable behavior from indolent disease to highly aggressive, progressive disease. There are distinguishing phenotypic features of sporadic and hereditary MTC. Activation or overexpression of cell surface receptors and up-regulation of intracellular signaling pathways in hereditary and sporadic MTC are involved in the disease pathogenesis. There has been an exponential rise in clinical trials with investigational agents, leading to approval of 2 medications for progressive, advanced MTC. Developments in understanding the pathogenesis of MTC will hopefully lead to more effective and less toxic treatments of this rare but difficult to treat cancer.

引用

页码：423 / +

页数：21

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