Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(I) complex of a monodentate secondary phosphine oxide ligand

被引：31
作者：
Dong, Kaiwu [1 ]
Li, Yang [1 ]
Wang, Zheng [1 ]
Ding, Kuiling [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2014年 / 1卷 / 02期
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; SUBSTITUTED ACRYLIC-ACIDS; DIPHOSPHINE LIGANDS; CROSS-COUPLINGS; 1,4-ADDITION; IMPACT;
D O I：
10.1039/c3qo00042g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Rh-I complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of alpha-arylacrylic and beta-arylbut-3-enoic acids, providing the corresponding chiral alpha-arylpropanoic and beta-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.
引用
收藏
页码：155 / 160
页数：6
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