Serial measurements of the Nt-ProBNP during the dry state in patients with systolic heart failure are predictors of the long-term prognosis

被引：13
|
作者：
Sargento, Luis [1 ]
Longo, Susana [1 ]
Lousada, Nuno [1 ]
dos Reis, Roberto Palma [1 ]
机构：
[1] Lisbon North Hosp Ctr, Pulido Valente Hosp, Heart Failure Unit, Dept Cardiol, P-1750335 Lisbon, Portugal
来源：
BIOMARKERS | 2014年 / 19卷 / 04期
关键词：
Nt-ProBNP; prognosis; serial measurement; systolic heart failure; BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL VARIATION; VAL-HEFT; BNP; TRIAL; OUTPATIENTS; POPULATION; MANAGEMENT; MORTALITY; DIAGNOSIS;
D O I：
10.3109/1354750X.2014.910549
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To evaluate the long-term predictive value of serial Nt-ProBNP during dry-state in patients with systolic heart failure (SHF). Methods: Nt-ProBNP was measured quarterly during a 6-month dry-state period in 40 SHF outpatients. Events: all-cause mortality or hospitalization. Follow-up: 5 years. Results: The Nt-ProBNP >1000 pg/ml (baseline and 6 months) and the variation rate (VR) >30% were independently associated with the survival and composite endpoint curve. VR >30% added significant prognostic information to the single Nt-ProBNP 1000 pg/ml cut-off. Patients with at least one Nt-ProBNP determination >1000 pg/ml were at greater risk of death. Conclusion: Serial Nt-ProBNP measurements in patients with SHF during the dry-state are strong predictors of the long-term prognosis.
引用
收藏
页码：302 / 313
页数：12
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