Approach to critical illness myopathy and polyneuropathy in the older SARS-CoV-2 patients

被引:15
作者
McClafferty, Brendan [1 ]
Umer, Ibrahim [1 ]
Fye, Gary [1 ]
Kepko, Douglas [1 ]
Kalayanamitra, Ricci [2 ]
Shahid, Zainab [1 ]
Ramgobin, Devyani [3 ]
Cai, Alice [2 ]
Groff, Andrew [2 ]
Bhandari, Abani [6 ]
Aggarwal, Chander Shekher [5 ]
Patel, Ravi [4 ]
Bhatt, Dhirisha [4 ]
Polimera, Hyma [4 ]
Sahu, Nitasa [4 ]
Vunnam, Ramarao [4 ]
Golamari, Reshma [4 ]
Kumar, Ashutosh [7 ]
Jain, Rohit [4 ]
机构
[1] Lake Erie Coll Osteopath Med, 1858 W Grandview Blvd, Erie, PA 16509 USA
[2] Penn State Coll Med, Hershey, PA USA
[3] Touro Coll Osteopath Med, New York, NY USA
[4] Penn State Milton S Hershey Med Ctr, Dept Internal Med, Hershey, PA USA
[5] Univ Coll Med Sci, Delhi, India
[6] Tribhuvan Univ, Dept Internal Med, KISTMC, Nepal, India
[7] Penn State Milton S Hershey Med Ctr, Dept Pediat & Neurol, Hershey, PA USA
关键词
SARS-CoV-2; COVID-19; Critical illness myopathy; Critical illness polyneuropathy; Intensive care unit-acquired weakness; Older adults; ACQUIRED WEAKNESS; ANIMAL-MODEL; MUSCLE; MYOSIN; DEGENERATION; EXCITABILITY; MECHANISMS; NEUROPATHY; RESPONSES; SEPSIS;
D O I
10.1016/j.jocn.2020.07.058
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
One of the major concerns of the health care community and the public surrounding the SARS-CoV-2 pandemic is the availability and use of ventilators. Unprecedented surges of patients presented to intensive care units across the country, with older adults making up a large proportion of the patient population. This paper illustrates contemporary approaches to critical illness myopathy (CIM), critical illness polyneuropathy (CIP), and critical illness polyneuromyopathy (CIPNM) in older patients, including incidence, risk factors, mechanisms for pathology, diagnosis, contemporary treatment approaches, and outcomes. We hope that the following analysis may help educate clinicians and ultimately decrease the duration of the mechanical ventilation required by these patients, resulting in improved clinical outcomes and an increase in ventilator availability for other patients in need. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页码:241 / 245
页数:5
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