Effects of olefin substitution on the ring-closing metathesis of dienes

被引：258

作者：

Kirkland, TA ^{[1
]}

Grubbs, RH ^{[1
]}

机构：

[1] CALTECH,ARNOLD & MABEL BECKMAN LABS CHEM SYNTHESIS,DIV CHEM & CHEM ENGN,PASADENA,CA 91125

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 21期

关键词：

D O I：

10.1021/jo970877p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium alkylidene 1 and molybdenum alkylidene 2 have been utilized in the ring-closing metathesis (RCM) of dienes containing gem-disubstituted olefins to yield td-and tetrasubstituted cyclic olefins. Dienes with sterically demanding and/or electron-withdrawing substituents such as Ph, CO2Me, and Bu-t were cyclized successfully with 2, but did not cyclize with 1. Tetrasubstituted cyclic olefins could be formed with 2, but not using alkylidene-1. Dienes with allylic functional groups yielded functionalized cyclic olefins when treated with 1.

引用

页码：7310 / 7318

页数：9

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