Weight loss and plasma lipids

被引:24
作者
Noakes, M [1 ]
Clifton, PM [1 ]
机构
[1] CSIRO Hlth Sci & Nutr, Adelaide, SA, Australia
关键词
D O I
10.1097/00041433-200002000-00010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although weight loss is associated with improvements in the plasma lipid profile, factors other than weight loss per se are involved. Energy restriction resulting in even modest weight loss suppresses endogenous cholesterol synthesis, which contributes to observed decline in circulating lipid concentrations. Whether individuals have stabilized weight or are still actively losing weight affects the magnitude of LDL cholesterol reduction as well as the direction of HDL cholesterol change. Hence, it is important to consider the timing of lipid measurements in the interpretation of the plasma lipid response to weight loss. Another important factor is the dietary composition of the weight loss strategy, with evidence that dietary far, acid profile and amount can differentially influence the lipid response similar to that observed in energy balance studies. Other issues such as gender, and exercise during weight loss are also relevant. However, whether the lipid changes that are observed in the short term are sustained in the long term and whether the manner of weight loss has any impact on long-term outcomes remains to be determined. Curr Opin Lipidol 11:65-70. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:65 / 70
页数:6
相关论文
共 43 条
[1]   Insulin resistance and fat patterning with aging: Relationship to metabolic risk factors for cardiovascular disease [J].
Cefalu, WT ;
Werbel, S ;
Bell-Farrow, AD ;
Terry, JG ;
Wang, ZQ ;
Opara, EC ;
Morgan, T ;
Hinson, WH ;
Crouse, JR .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (04) :401-408
[2]   EFFECTS OF WEIGHT-REDUCTION ON BLOOD-LIPIDS AND LIPOPROTEINS - A METAANALYSIS [J].
DATTILO, AM ;
KRISETHERTON, PM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1992, 56 (02) :320-328
[3]   INSULIN RESISTANCE - A MULTIFACETED SYNDROME RESPONSIBLE FOR NIDDM, OBESITY, HYPERTENSION, DYSLIPIDEMIA, AND ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE [J].
DEFRONZO, RA ;
FERRANNINI, E .
DIABETES CARE, 1991, 14 (03) :173-194
[4]   EFFECT OF AN AMERICAN-HEART-ASSOCIATION DIET, WITH OR WITHOUT WEIGHT-LOSS, ON LIPIDS IN OBESE MIDDLE-AGED AND OLDER MEN [J].
DENGEL, JL ;
KATZEL, LI ;
GOLDBERG, AP .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 62 (04) :715-721
[5]   EXCESS BODY-WEIGHT - AN UNDERRECOGNIZED CONTRIBUTOR TO HIGH BLOOD CHOLESTEROL LEVELS IN WHITE AMERICAN MEN [J].
DENKE, MA ;
SEMPOS, CT ;
GRUNDY, SM .
ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (09) :1093-1103
[6]   DIFFERENTIAL-EFFECTS OF BODY FATNESS AND BODY-FAT DISTRIBUTION ON RISK-FACTORS FOR CARDIOVASCULAR-DISEASE IN WOMEN - IMPACT OF WEIGHT-LOSS [J].
DENNIS, KE ;
GOLDBERG, AP .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (10) :1487-1494
[7]   Weight loss due to energy restriction suppresses cholesterol biosynthesis in overweight, mildly hypercholesterolemic men [J].
Di Buono, M ;
Hannah, JS ;
Katzel, LI ;
Jones, PJH .
JOURNAL OF NUTRITION, 1999, 129 (08) :1545-1548
[8]   Lipoprotein response to a national cholesterol education program step II diet with and without energy restriction [J].
Flynn, MM ;
Zmuda, JM ;
Milosavljevic, D ;
Caldwell, MJ ;
Herbert, PN .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (07) :822-826
[9]   High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis [J].
Garg, A .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (03) :577S-582S
[10]  
Golay A, 1996, INT J OBESITY, V20, P1067