Surfactive water-soluble copolymers for the preparation of controlled surface nanoparticles by double emulsion/solvent evaporation

被引：22

作者：

Chognot, David ^{[1
]}

Leonard, Michele ^{[1
]}

Six, Jean-Luc ^{[1
]}

Dellacherie, Edith ^{[1
]}

机构：

[1] Ecole Natl Super Ind Chim, Inst Natl Polytech Lorraine, CNRS, Lab Chim Phys Macromol,UMR 7568, F-54001 Nancy, France

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2006年 / 51卷 / 01期

关键词：

polymeric surfactants; double emulsion/solvent evaporation; MPEO-covered PLA nanoparticles; colloidal stability;

D O I：

10.1016/j.colsurfb.2006.04.003

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We have already shown that polylactide (PLA) nanoparticles covered with a hydrophilic polymeric layer can be prepared by simple emulsion/solvent evaporation by using amphiphilic copolymers as surfactants during the procedure. The external layer is then constituted by the hydrophilic part of the macromolecular surfactant. This kind of nanospheres is useful for the encapsulation of lipohilic molecules. The use of amphiphilic copolymers as surfactants in the preparation of PLA nanospheres with controlled surface properties, was then applied to the double emulsion/solvent evaporation procedure. The aim was to allow the encapsulation of water-soluble bioactive molecules in PLA particles with controlled surface properties. In this paper, we describe the results obtained with three different water-soluble monomethoxypolyethylene oxide (MPEO)-b-PLA diblock copolymers used as surfactants in the preparation of nanoparticles by double emulsion/solvent evaporation. After organic solvent evaporation, the obtained nanospheres were proved to be really covered by a MPEO layer whose characteristics were determined. It was firstly shown that the MPEO-covered particles did not flocculate at 25 degrees C, even in 4 M NaCl while suspensions of bare nanospheres were destabilized for a NaCl concentration as low as 0.04 M. On the other hand, the suspensions of MPEO-covered nanoparticles in 0.3 M Na2SO4 were found to be very sensitive to temperature as they flocculated at a temperature lying between 45 and 55 degrees C depending on the MPEO-b-PLA composition. This property was attributed to the fact that MPEO is a polymer with a low critical solution temperature. The concentration of MPEO at the nanoparticle surface was then calculated for the three kinds of particles, from the initial flocculation temperature, and was found to be comparable to the value determined directly.(c) 2006 Elsevier B.V. All rights reserved.

引用

页码：86 / 92

页数：7