Adult Patient with Epstein-Barr Virus (EBV)-Associated Lymphoproliferative Disorder: Chronic Active EBV Infection or de novo Extranodal Natural Killer (NK)/T-cell Lymphoma, Nasal Type?

被引：8

作者：

Ohtsuka, Rie ^{[1
]}

Abe, Yasunobu ^{[1
]}

Sada, Eriko ^{[1
]}

Kiyasu, Junichi ^{[1
]}

Ashikari, Akiyo ^{[1
]}

Shiratsuchi, Motoaki ^{[1
]}

Nishimura, Junji ^{[2
]}

Takayanagi, Ryoichi ^{[1
]}

Ohshima, Koichi ^{[3
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Dept Clin Immunol, Fukuoka 812, Japan

[3] Kurume Univ, Sch Med, Dept Pathol, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2009年 / 48卷 / 06期

关键词：

chronic active Epstein-Barr virus infection; extranodal NK/T-cell lymphoma; nasal type; adult patient; YOUNG-ADULTS; CHILDREN; DISEASE; STATES;

D O I：

10.2169/internalmedicine.48.1346

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic active Epstein-Barr virus (EBV) infection, which is considered to be a childhood disease, often develops into natural killer (NK) or T-cell lymphoma after recurrent infectious mononucleosis (IM)-like symptoms. We describe a 56-year-old woman who developed NK-cell lymphoma after 9 months of recurrent IM-like symptoms. The patient had an unusual anti-EBV antibody profile. Increased levels of EBV genome were detected in the liver and peripheral blood. Several chemotherapy regimens were ineffective, and the patient died of progression of lymphoma. Certain subtypes of NK-cell lymphoma showing a long-lasting prodrome related to chronic EBV infection may exist.

引用

页码：471 / 474

页数：4

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