Synthesis of 1-(4-bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one

被引：0

作者：

Wang, Linxiao ^{[1
]}

Lu, Wei ^{[1
]}

Xiao, Zhen ^{[1
]}

Zhou, Min ^{[1
]}

Li, Jiqing ^{[1
]}

Xu, Shan ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering (MMME 2016) | 2016年 / 79卷

关键词：

1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one; Pyridin-4-ol; Synthesis;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from pyridin-4-ol (7) and 4-bromo-2-fluoroaniline through five steps including nitration, chlorination, N-alkylation, reduction and condensation. The structures of the compound 8 was confirmed by H-1 NMR spectrums and target compound 1 confirmed by Mass spectra.

引用

页码：473 / 475

页数：3

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