Simulation of spiral wave superseding in the Luo-Rudy anisotropic model of cardiac tissue with circular-shaped fibres

被引:9
作者
Epanchintsev, Timofei [1 ,3 ]
Pravdin, Sergei [2 ,3 ]
Panfilov, Alexander [3 ,4 ,5 ]
机构
[1] Krasovskii Inst Math & Mech, 16 S Kovalevskaya St, Ekaterinburg 620990, Russia
[2] Krasovskii Inst Math & Mech, Math Modelling Cardiol Dept, 16 S Kovalevskaya St, Ekaterinburg 620990, Russia
[3] Ural Fed Univ, HPC Dept, 19 Mira St, Ekaterinburg 620002, Russia
[4] Ural Fed Univ, Lab Math Modelling Physiol & Med, 19 Mira St, Ekaterinburg 620002, Russia
[5] Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium
基金
俄罗斯科学基金会;
关键词
Anisotropy; Spiral wave; Overdrive pacing; Heart model; Low-voltage cardioversion; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; VENTRICULAR-TACHYCARDIA; MYOCARDIUM; MECHANISMS; DYNAMICS; BREAKUP;
D O I
10.1016/j.jocs.2019.02.001
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Abnormal excitation of the heart can cause cardiac arrhythmias, which may result in cardiac arrest and sudden cardiac death. Currently, the most efficient way to stop lethal cardiac arrhythmias is high-voltage defibrillation. This method is extremely effective. However, it has serious disadvantages, as it is painful and can damage the heart. In this paper, we studied in-silico process of overdrive pacing of arrhythmia sources, which in some cases can also stop cardiac arrhythmias and does not require the application of high voltages. We investigated this process in the Luo-Rudy ionic model for cardiac cells and in case of circular anisotropy of cardiac tissue. We showed that we could efficiently remove the arrhythmia sources in the form of rotating spiral waves in such a system in a certain parameter range. However, anisotropy by itself can cause additional dynamics of the spiral waves: drift and break up. We studied manifestations of these effects and discussed their possible effects on the overdrive pacing. This paper is an extended version of the paper [1] which was submitted to the ICCS 2018 conference proceedings. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 35 条
[11]   Mechanisms of vortices termination in the cardiac muscle [J].
Hornung, D. ;
Biktashev, V. N. ;
Otani, N. F. ;
Shajahan, T. K. ;
Baig, T. ;
Berg, S. ;
Han, S. ;
Krinsky, V. I. ;
Luther, S. .
ROYAL SOCIETY OPEN SCIENCE, 2017, 4 (03)
[12]   A biophysical model for defibrillation of cardiac tissue [J].
Keener, JP ;
Panfilov, AV .
BIOPHYSICAL JOURNAL, 1996, 71 (03) :1335-1345
[13]   Spiral wave dynamics under feedback derived from a confined circular domain [J].
Kheowan, O.-U. ;
Chan, C.-K. ;
Zykov, V.S. ;
Rangsiman, O. ;
Müller, S.C. .
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 2001, 64 (3 II) :352011-352014
[14]   INTERACTION OF ROTATING WAVES IN AN ACTIVE-CHEMICAL MEDIUM [J].
KRINSKY, VI ;
AGLADZE, KI .
PHYSICA D, 1983, 8 (1-2) :50-56
[15]   LiFlow web service for quick launch of large experiment series on supercomputers [J].
Kuklin, Evgeniy ;
Pravdin, Sergei .
7TH INTERNATIONAL YOUNG SCIENTISTS CONFERENCE ON COMPUTATIONAL SCIENCE, YSC2018, 2018, 136 :44-51
[16]   Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction [J].
Li, Wenwen ;
Ripplinger, Crystal M. ;
Lou, Qing ;
Efimov, Igor R. .
HEART RHYTHM, 2009, 6 (07) :1020-1027
[17]   A MODEL OF THE VENTRICULAR CARDIAC ACTION-POTENTIAL - DEPOLARIZATION, REPOLARIZATION, AND THEIR INTERACTION [J].
LUO, CH ;
RUDY, Y .
CIRCULATION RESEARCH, 1991, 68 (06) :1501-1526
[18]   Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models [J].
Markhasin, VS ;
Solovyova, O ;
Katsnelson, LB ;
Protsenko, Y ;
Kohl, P ;
Noble, D .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2003, 82 (1-3) :207-220
[19]  
Mena A., 2014, P 41 INT C EL ICE 20
[20]  
Nakazawa K, 2000, CLINICAL APPLICATION OF COMPUTATIONAL MECHANICS TO THE CARDIOVASCULAR SYSTEM, P217