The Role of Genetic Markers in the Evaluation and Management of Thyroid Nodules

被引：11
作者：
Parangi, Sareh [1 ]
Suh, Hyunsuk [2 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Unit Endocrine Surg, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Dept Gen Surg, Boston, MA 02115 USA
来源：
SURGICAL CLINICS OF NORTH AMERICA | 2014年 / 94卷 / 03期
关键词：
Thyroid nodules; Indeterminate cytology; Molecular markers; Genetic testing; TERT PROMOTER MUTATIONS; BRAF MUTATION; EXPRESSION CLASSIFIER; INDETERMINATE; IMPACT; PREVALENCE; CARCINOMA; BENIGN; REARRANGEMENT; ASSOCIATION;
D O I：
10.1016/j.suc.2014.03.001
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Thyroid nodules are common, with increasing incidence, but only 5% to 15% of nodules are malignant. Genetic markers should only be used as an ancillary diagnostic tool for indeterminate thyroid nodules. Veracyte Afirma may improve the diagnostic accuracy for a subset of indeterminate cytologic diagnosis. Overall clinical, imaging, and cytopathologic evaluation in addition to patient preference should guide the management of indeterminate nodules. Further multicentered and independent validation studies are needed in order to prove the efficacy of commercially available genetic markers.
引用
收藏
页码：515 / +
页数：15
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