The multidrug resistance protein family

被引：535
作者：
Borst, P
Evers, R
Kool, M
Wijnholds, J
机构：
[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1461卷 / 02期
关键词：
multidrug resistance protein; multidrug resistance; protein routing; glutathione-drug conjugate pump; GSH; cisplatin;
D O I：
10.1016/S0005-2736(99)00167-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：347 / 357
页数：11
相关论文
共 59 条
  • [1] Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
    Allikmets, R
    Gerrard, B
    Hutchinson, A
    Dean, M
    [J]. HUMAN MOLECULAR GENETICS, 1996, 5 (10) : 1649 - 1655
  • [2] Membrane topology and glycosylation of the human multidrug resistance-associated protein
    Bakos, E
    Hegedus, T
    Hollo, Z
    Welker, E
    Tusnady, GE
    Zaman, GJR
    Flens, MJ
    Varadi, A
    Sarkadi, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12322 - 12326
  • [3] Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain
    Bakos, E
    Evers, R
    Szakács, G
    Tusnády, GE
    Welker, E
    Szabó, K
    de Haas, M
    van Deemter, L
    Borst, P
    Váradi, A
    Sarkadi, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) : 32167 - 32175
  • [4] Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione
    Ballatori, N
    Rebbeor, JF
    [J]. SEMINARS IN LIVER DISEASE, 1998, 18 (04) : 377 - 387
  • [5] Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
    Belinsky, MG
    Bain, LJ
    Balsara, BB
    Testa, JR
    Kruh, GD
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (22) : 1735 - 1741
  • [6] Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans
    Broeks, A
    Gerrard, B
    Allikmets, R
    Dean, M
    Plasterk, RHA
    [J]. EMBO JOURNAL, 1996, 15 (22) : 6132 - 6143
  • [7] Buchler M, 1996, J BIOL CHEM, V271, P15091
  • [8] OVEREXPRESSION OF A TRANSPORTER GENE IN A MULTIDRUG-RESISTANT HUMAN LUNG-CANCER CELL-LINE
    COLE, SPC
    BHARDWAJ, G
    GERLACH, JH
    MACKIE, JE
    GRANT, CE
    ALMQUIST, KC
    STEWART, AJ
    KURZ, EU
    DUNCAN, AMV
    DEELEY, RG
    [J]. SCIENCE, 1992, 258 (5088) : 1650 - 1654
  • [9] Cole SPC, 1999, J NATL CANCER I, V91, P888, DOI 10.1093/jnci/91.10.888
  • [10] Cui YH, 1999, MOL PHARMACOL, V55, P929
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