Amyotrophic lateral sclerosis progression: Iran-ALS clinical registry, a multicentre study

被引：9

作者：

Shamshiri, Hosein ^{[1
]}

Fatehi, Farzad ^{[1
]}

Davoudi, Farnoush ^{[2
]}

Mir, Elham ^{[3
]}

Pourmirza, Behin ^{[3
]}

Abolfazli, Roya ^{[1
]}

Etemadifar, Masoud ^{[4
]}

Harirchian, Mohammad Hossein ^{[1
]}

Gharagozli, Koroush ^{[5
]}

Ayromlou, Hormoz ^{[6
]}

Basiri, Keivan ^{[4
]}

Zamani, Babak ^{[7
]}

Rohani, Mohammad ^{[7
]}

Sedighi, Behnaz ^{[8
]}

Roudbari, Ali ^{[9
]}

Kasmaei, Hossein Delavar ^{[5
]}

Nikkhah, Karim ^{[10
]}

Naeini, Alireza Ranjbar ^{[11
]}

Nafissi, Shahriar ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Neurol, Iranian Ctr Neurol Res, Tehran, Iran

[2] Iran Univ Med Sci, Dept Community Med, Tehran, Iran

[3] Sanofi Med Dept, Tehran, Iran

[4] Isfahan Univ Med Sci, Dept Neurol, Esfahan, Iran

[5] Shahid Beheshti Med Univ, Dept Neurol, Tehran, Iran

[6] Tabriz Univ Med Sci, Dept Neurol, Tehran, Iran

[7] Iran Univ Med Sci, Dept Neurol, Tehran, Iran

[8] Kerman Univ Med Sci, Dept Neurol, Kerman, Iran

[9] Guilan Univ Med Sci, Dept Neurol, Tehran, Iran

[10] Mashhad Univ Med Sci, Dept Neurol, Tehran, Iran

[11] Aja Med Univ, Tehran, Iran

来源：

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION | 2015年 / 16卷 / 7-8期

关键词：

Amyotrophic lateral sclerosis; progression rate; Manual Muscle Test scoring; revised ALS Functional Rating Scale; MOTOR-NEURON DISEASE; PROGNOSTIC-FACTORS; RILUZOLE; SURVIVAL; EPIDEMIOLOGY;

D O I：

10.3109/21678421.2015.1074698

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study was designed to evaluate ALS progression among different subgroups of Iranian patients.Three hundred and fifty-eight patients from centres around the country were registered and their progression rate was evaluated using several scores including Manual Muscle Test scoring (MMT) and the revised ALS Functional Rating Scale (ALSFRS-R). Progression rate was analysed separately in subgroups regarding gender, onset site, stage of disease and riluzole consumption. A significant difference in MMT deterioration rate (p=0.01) was noted between those who used riluzole and those who did not. No significant difference was observed in progression rates between male/female and bulbar-onset/limb-onset groups using riluzole. In conclusion, riluzole has a significant effect on muscle force deterioration rate but not functional scale. Progression rate was not influenced by site of onset or gender.

引用

页码：506 / 511

页数：6

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