EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

被引：34
|
作者：
Doma, Eszter [1 ]
Rupp, Christian [1 ]
Baccarini, Manuela [1 ]
机构：
[1] Univ Vienna, Dept Microbiol Immunol & Genet, Max F Perutz Labs, A-1030 Vienna, Austria
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 10期
关键词：
epidermis; hair follicle; stem cell; EGFR signaling; Ras; Raf; SSC; BCC; wound healing; GROWTH-FACTOR RECEPTOR; LABEL-RETAINING CELLS; BETA-CATENIN; TGF-ALPHA; SONIC-HEDGEHOG; MOUSE SKIN; PROGENITOR POPULATION; PROLIFERATIVE UNIT; COSTELLO-SYNDROME; SOLAR KERATOSES;
D O I：
10.3390/ijms141019361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin development and tumor formation. While research mainly focuses on its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis. In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions.
引用
收藏
页码：19361 / 19384
页数：24
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