Improved synthesis of N-substituted 2,3-pyridinedicarboximides with microwave irradiation

被引：0
|
作者：
Blanco, MM [1 ]
Levin, GJ [1 ]
Schapira, CB [1 ]
Perillo, IA [1 ]
机构：
[1] Univ Buenos Aires, Fac Farm & Bioquim, Dept Organ Chem, RA-1113 Buenos Aires, DF, Argentina
来源：
HETEROCYCLES | 2002年 / 57卷 / 10期
关键词：
quinolinimide; N-alkylation; aminolysis; dehydrative condensation; nicotinamide;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The microwave-induced synthesis of N-substituted 2,3-pyridinedicarboximides (1) by means of two different approaches is presented. One involves direct N-alkylation of quinolinimide (2) (Method A) and the other, dehydrative condensation of quinolinic anhydride (4) and amines (Method B). Reactions resulted highly accelerated, with improved yields in relation to those obtained by conventional heating. The scope and limitations of each method and its variants are discussed.
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页码：1881 / 1890
页数：10
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