How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions

被引：36

作者：

Gianchecchi, Elena ^{[1
]}

Manenti, Alessandro ^{[1
,2
]}

Kistner, Otfried ^{[1
]}

Trombetta, Claudia ^{[3
]}

Manini, Ilaria ^{[3
]}

Montomoli, Emanuele ^{[1
,2
,3
]}

机构：

[1] VisMederi Srl, Str Petriccio & Belriguardo 35, I-53100 Siena, Italy

[2] VisMederi Res Srl, Siena, Italy

[3] Univ Siena, Dept Mol & Dev Med, Siena, Italy

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2019年 / 13卷 / 05期

关键词：

enzyme-linked immunosorbent assay; influenza vaccines; influenza virus; mucosal immunity; secretory IgAs; A VIRUS-INFECTION; RESPIRATORY-TRACT; IMMUNE-RESPONSE; IGA ANTIBODIES; MONOMERIC IGA; SECRETORY IGA; HETEROSUBTYPIC IMMUNITY; INTRANASAL VACCINATION; CELL RESPONSES; B-CELL;

D O I：

10.1111/irv.12664

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Secretory IgAs (sIgA) constitute the principal isotype of antibodies present in nasal and mucosal secretions. They are secreted by plasma cells adjacent to the mucosal epithelial cells, the site where infection occurs, and are the main humoral mediator of mucosal immunity. Mucosally delivered vaccines, such as live attenuated influenza vaccine (LAIV), are able to mimic natural infection without causing disease or virus transmission and mainly elicit a local immune response. The measurement of sIgA concentrations in nasal swab/wash and saliva samples is therefore a valuable tool for evaluating their role in the effectiveness of such vaccines. Here, we describe two standardized assays (enzyme-linked immunosorbent assay and microneutralization) available for the quantification of sIgA and discuss the advantages and limitations of their use.

引用

页码：429 / 437

页数：9

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