Oxime-Mediated Facile Access to 5-Methylisoxazoles and Applications in the Synthesis of Valdecoxib and Oxacillin

被引：60

作者：

Dong, Kui-Yong ^{[1
,2
]}

Qin, Hai-Tao ^{[1
,2
]}

Bao, Xing-Xing ^{[1
,2
]}

Liu, Feng ^{[1
,2
]}

Zhu, Chen ^{[3
,4
]}

机构：

[1] Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 20期

基金：

中国国家自然科学基金;

关键词：

BETA; GAMMA-UNSATURATED OXIMES; SELECTIVE INHIBITOR; IBOTENIC ACID; DELTA(2)-ISOXAZOLINES; ISOXAZOLINES; CLOXACILLIN; MUSCIMOL; POTENT; COX-2;

D O I：

10.1021/ol502246t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-Catalyzed efficient synthesis of 5 methylisoxazoless Via oxime-mediated functionalization of unactivated olefins is described. The reaction affords'a"Variety: of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the imethod, the rapid synthesis of valdecoxib and oxacillin is reported.

引用

页码：5266 / 5268

页数：3

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