Sustainability in the biopharmaceutical industry: Seeking a holistic perspective

被引:31
作者
Lalor, Fergal [1 ]
Fitzpatrick, John [1 ]
Sage, Colin [2 ]
Byrne, Edmond [1 ]
机构
[1] Univ Coll Cork, Dept Proc & Chem Engn, Coll Rd, Cork, Ireland
[2] Univ Coll Cork, Dept Geog, Cork, Ireland
关键词
Biopharmaceuticals; Sustainability; Integrated perspective; Industrial ecology; Holistic approach; LIFE-CYCLE ASSESSMENT; FED-BATCH; CELL-CULTURE; SINGLE-USE; PERFUSION; OPTIMIZATION; IMPACT; PHARMACEUTICALS; TECHNOLOGY; CAPACITY;
D O I
10.1016/j.biotechadv.2019.03.015
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biopharmaceuticals manufacturing is a critical component of the modem healthcare system, with emerging new treatments composed of increasingly complex biomolecules offering solutions to chronic and debilitating disorders. While this sector continues to grow, it strongly exhibits "boom-to-bust" performance which threatens its long-term viability. Future trends within the industry indicate a shift towards continuous production systems using single use technologies that raises sustainability issues, yet research in this area is sparse and lacks consideration of the complex interactions between environmental, social and economic concerns. The authors outline a sustainability-focused vision and propose opportunities for research to aid the development of a more integrated approach that would enhance the sustainability of the industry.
引用
收藏
页码:698 / 707
页数:10
相关论文
共 53 条
[1]  
[Anonymous], 2013, THESIS VRIJE U
[2]  
Barrett M., 2018, LIVING PLANET REPORT
[3]   The special case of gene therapy pricing [J].
Brennan, Troyen A. ;
Wilson, James M. .
NATURE BIOTECHNOLOGY, 2014, 32 (09) :874-876
[4]   Life-cycle and cost of goods assessment of fed-batch and perfusion-based manufacturing processes for mAbs [J].
Bunnak, Phumthep ;
Allmendinger, Richard ;
Ramasamy, V. ;
Lettieri, Paola ;
Titchener-Hooker, Nigel J. .
BIOTECHNOLOGY PROGRESS, 2016, 32 (05) :1324-1335
[5]  
Byrne EP, 2016, WORLD SUSTAIN SER, P23, DOI 10.1007/978-3-319-32933-8_3
[6]   Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery [J].
Chahal, Parminder Singh ;
Schulze, Erica ;
Tran, Rosa ;
Montes, Johnny ;
Kamen, Amine A. .
JOURNAL OF VIROLOGICAL METHODS, 2014, 196 :163-173
[7]   Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation [J].
Conley, Lynn ;
Tao, Yinying ;
Henry, Alexis ;
Koepf, Edward ;
Cecchini, Douglas ;
Pieracci, John ;
Ghose, Sanchayita .
BIOTECHNOLOGY AND BIOENGINEERING, 2017, 114 (04) :813-820
[8]   High-titer adenovirus vector production in 293S cell perfusion culture [J].
Cortin, V ;
Thibault, J ;
Jaeob, D ;
Garnier, A .
BIOTECHNOLOGY PROGRESS, 2004, 20 (03) :858-863
[9]   Glycosylation: impact, control and improvement during therapeutic protein production [J].
Costa, Ana Rita ;
Rodrigues, Maria Elisa ;
Henriques, Mariana ;
Oliveira, Rosario ;
Azeredo, Joana .
CRITICAL REVIEWS IN BIOTECHNOLOGY, 2014, 34 (04) :281-299
[10]   Drug pipeline: 4Q17 [J].
DeFrancesco, Laura .
NATURE BIOTECHNOLOGY, 2018, 36 (02) :130-130