A small-sized benzothiazole-indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

被引：23

作者：

Zheng, Bo-Xin ^{[1
]}

She, Meng-Ting ^{[1
]}

Long, Wei ^{[1
]}

Xu, Yong-Yu ^{[1
]}

Zhang, Yi-Han ^{[1
]}

Huang, Xuan-He ^{[1
]}

Liu, Wenjie ^{[3
,4
]}

Hou, Jin-Qiang ^{[3
,4
]}

Wong, Wing-Leung ^{[2
,5
]}

Lu, Yu-Jing ^{[1
]}

机构：

[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol Chem Technol, State Key Lab Chem Biol & Drug Discovery, Hung Hom,Kowloon, Hong Kong, Peoples R China

[3] Lakehead Univ, Dept Chem, 980 Oliver Rd, Thunder Bay, ON P7B 6V4, Canada

[4] Thunder Bay Reg Hlth Res Inst, 980 Oliver Rd, Thunder Bay, ON P7B 6V4, Canada

[5] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 95期

关键词：

SMALL-MOLECULE; THIOFLAVIN T; DNA;

D O I：

10.1039/d0cc06525k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa).

引用

页码：15016 / 15019

页数：4

共 25 条

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