Hepatoprotective Triterpenoid Saponins from Callicarpa nudiflora

被引：30

作者：

Huang, Bo ^{[1
,2
]}

Fu, Hui-Zheng ^{[1
]}

Chen, Wei-Kang ^{[1
]}

Luo, Yue-Hua ^{[1
]}

Ma, Shuang-Cheng ^{[3
]}

机构：

[1] Jiangxi Prov Engn Res Ctr Drug & Med Device Qual, Jiangxi Prov Inst Drug & Food Control, Nanchang 330029, Peoples R China

[2] Nanchang Univ, Dept Pharmaceut, Nanchang 330006, Peoples R China

[3] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Callicarpa nudiflora; triterpenoid saponin; hepatoprotective activity; CHEMICAL-CONSTITUENTS; GLYCOSIDES; LEAVES;

D O I：

10.1248/cpb.c14-00159

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new triterpenoid saponins, 2 alpha,3 alpha,19 alpha,24-tetrahydroxyolean-12-en-28-oic-acid 28-O-beta-D-glucopyranosyl ester (1), 2 alpha,3 alpha,19 alpha,23-tetrahydroxyolean-12-en-28-oic-acid 28-O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (2), 2 alpha,3 alpha,19 alpha-trihydroxyolean-12-en-28-oic-acid 28-O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (3), 2 alpha,3 alpha,23,29-tetrahydroxyurs-12,19-dien-28-oic-acid 28-O-beta-D-glucopyranosyl ester (4), together with three known compounds (5-7), were isolated from the leaves of Callicarpa nudiflora HOOK. Their structures were established by means of spectroscopic methods and chemical evidence. Hepatoprotective activities of the isolated compounds against D-galactosamine-induced toxicity have been tested. Among them, compounds 1-3 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.

引用

页码：695 / 699

页数：5

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