TPO antibody positivity and adverse pregnancy outcomes

被引：49

作者：

Dhillon-Smith, R. K. ^{[1
,2
,3
]}

Coomarasamy, A. ^{[1
,2
,3
]}

机构：

[1] Univ Birmingham, Coll Med & Dent Sci, Inst Metab & Syst Res, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Coll Med & Dent Sci, Tommys Ctr Miscarriage Res, Birmingham B15 2TT, W Midlands, England

[3] Birmingham Womens & Childrens Fdn Trust, Ctr Womens & Newborn Hlth, Birmingham B15 2TG, W Midlands, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2020年 / 34卷 / 04期

基金：

英国医学研究理事会;

关键词：

thyroid peroxidase antibodies; thyroid autoimmunity; miscarriage; preterm birth; levothyroxine; IN-VITRO FERTILIZATION; MATERNAL THYROID AUTOIMMUNITY; SUBCLINICAL HYPOTHYROIDISM; THYROGLOBULIN ANTIBODIES; LEVOTHYROXINE TREATMENT; EUTHYROID WOMEN; ANTITHYROID ANTIBODIES; RECURRENT MISCARRIAGE; PEROXIDASE ANTIBODIES; COST-EFFECTIVENESS;

D O I：

10.1016/j.beem.2020.101433

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid autoimmunity (TAI) is prevalent amongst women of reproductive age. TAI describes the presence of circulating antithyroid autoantibodies that are targeted against the thyroid, with or without thyroid dysfunction. Thyroid peroxidase antibodies (TPOAb) are the most common anti-thyroid autoantibodies. Around 10% of biochemically euthyroid individuals also have an elevated TPOAb titre. Many studies have linked the presence of TPOAb to adverse maternal and fetal outcomes in pregnancy, in particular miscarriage and pre-term birth, even in the absence of thyroid dysfunction. The causal pathway is poorly understood and few trials have looked to find treatments to reduce adverse outcomes. This review discusses in detail the associated adverse outcomes of TPOAb in pregnancy and the results of trials exploring methods to reduce such outcomes. Recommendations for counselling and monitoring of women with TPOAb and suggested areas for future work are also outlined. Crown Copyright (c) 2020 Published by Elsevier Ltd. All rights reserved.

引用

页数：12

共 78 条

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