Biomedical Hydrogels Fabricated Using Diels-Alder Crosslinking

被引:37
作者
Cadamuro, Francesca [1 ]
Russo, Laura [1 ]
Nicotra, Francesco [1 ]
机构
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Piazza Sci 2, I-20126 Milan, Italy
关键词
Diels– Alder; Bio‐ conjugation; Click chemistry; Biomaterials; Hydrogels; CLICK CHEMISTRY; DESIGN;
D O I
10.1002/ejoc.202001042
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The Diels-Alder (DA) cycloaddition is one of the best methods for biomaterials conjugation to generate tools for biomedical applications. It is a biocompatible one-step reaction, exploiting functional groups absent in natural biopolymers, doesn't require catalysts, and doesn't generate side products, an ideal "click reaction". In this review we provide an overview on the recent examples in which the DA cycloaddition has been exploited in nanomedicine. Nanoparticles for drug delivery or diagnosis, and nanostructured biomaterials for regenerative medicine, have been efficiently generated exploiting the DA reaction to crosslink the polymeric components, in order to obtain nanoparticles or scaffolds with the required chemical and morphological properties, and to conjugate targeting agents or signalling molecules.
引用
收藏
页码:374 / 382
页数:9
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