The polygenic profile of Russian football players

被引：54
作者：
Egorova, Emiliya S. [1 ]
Borisova, Alyona V. [1 ]
Mustafina, Leysan J. [1 ]
Arkhipova, Alina A. [1 ]
Gabbasov, Rashid T. [1 ]
Druzhevskaya, Anastasiya M. [2 ]
Astratenkova, Irina V. [2 ]
Ahmetov, Ildus I. [1 ]
机构：
[1] Kazan State Med Univ, Mol Genet Lab, Kazan, Russia
[2] St Petersburg Res Inst Phys Culture, Sports Genet Lab, St Petersburg, Russia
来源：
JOURNAL OF SPORTS SCIENCES | 2014年 / 32卷 / 13期
关键词：
selection; talent identification; genotype; polymorphism; polygenic; CONVERTING ENZYME GENOTYPE; UNCOUPLING PROTEIN-2 GENE; HUMAN SKELETAL-MUSCLE; SOCCER PLAYERS; PHYSICAL PERFORMANCE; TALENT IDENTIFICATION; ACTN3; GENOTYPE; ATHLETE STATUS; ELITE SOCCER; POLYMORPHISM;
D O I：
10.1080/02640414.2014.898853
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
Research concerned with predictors of talent in football has highlighted a number of potentially important and partially inherited measures such as body size, anaerobic power, aerobic capacity, agility, psychological profile, game intelligence and susceptibility to injuries. Genotyping for performance-associated DNA polymorphisms at an early age could be useful in predicting later success in football. The aim of the study was to investigate individually and in combination the association of common gene polymorphisms with football player's status. A total of 246 Russian football players and 872 controls were genotyped for 8 gene polymorphisms, which were previously reported to be associated with athlete status. Four alleles (ACED, ACTN3 Arg577, PPARA rs4253778 C and UCP2 55Val) were first identified, showing discrete associations with football player's status. Next, we determined the total genotype score (TGS, from the accumulated combination of the 4 polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in football players (52.0 (17.6) vs. 41.3 (15.5); P < 0.0001) than in controls. These data suggest that the likelihood of becoming a football player depends on the carriage of a high number of "favourable" gene variants.
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收藏
页码：1286 / 1293
页数：8
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