CLINICAL FEATURES AND RISK FACTORS ANALYSIS OF DELAYED ENCEPHALOPATHY AFTER ACUTE CARBON MONOXIDE POISONING

Objective: To explore clinical features and risk factors of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods: A total of 184 ACMP patients admitted in the Department of Neurology, The First Hospital of Lanzhou University from 2008 to 2016 were recruited as study subjects. They were randomly divided into the study group (DEACMP) and the control group (non-DEACMP). Twelve (12) indices (age, sex, coma time and JSC score, COHb, WBC, CK, CK-MB, LDH, abnormal skull CT, hospitalization time, and hyperbaric oxygen therapy) of patients in the two groups were analyzed. Results: ACMP patients in two groups, there were 114 cases with coma time of patients in the control group was 12h or less 12h, 19 patients with 13h to 24h, 11 cases with 25h to 48h, 4 cases with over 48h. 36 delayed encephalopathy cases in 184 ACMP patients were the study group. The incidence rate was 19.56%. There were 13 cases with coma time of patients in the study group was 12h or less 12h, 11 patients with 13h to 24h, 5 cases with 25h to 48h, 7 cases with over 48h. The coma time in the study group was longer. Patients in the study group compared with the control group in ratio of male and female, there were no differences in mean age and laboratory indexes (COHb concentration and WBC), data had no statistical significance (P > 0.05). According to Japan coma scale (JSC) scoring, it was found that consciousness dysfunction when admitted into hospital in the study group was worse compared with the control group. At the same time, Cranial CT in the study group showed that patients with hypoxic hypoxia brain change, which compared with the control group, the percentage was more high, differences had statistical significance (P < 0.01). According to indexes in experiment, it showed that CK, CK-MB and LDH level significantly increased in the study group compared with the control group, differences had statistical significance (P < 0.01). Compared with the control group, hospitalization time in the study group was longer and hyperbaric oxygen treatment had been prolonged. Differences between two groups had statistical significance (P < 0.01). Conclusion: DEACMP patients should particularly pay attention to strengthen clinical monitor to decrease incidence of DEACMP.