Genomics and proteomics tools for compound mode-of-action studies in drug discovery

被引：12
作者：
Kley, N
Ivanov, I
Meier-Ewert, S
机构：
[1] GPC Bitoech Inc, Waltham, MA 02451 USA
[2] GPC Biotech AG, D-82152 Martinsried, Germany
来源：
PHARMACOGENOMICS | 2004年 / 5卷 / 04期
关键词：
chemical biology; chemical genetics; gene expression; molecular interaction; mode of action; pharmacogenomics; pharmacoproteomics; small molecule drugs;
D O I：
10.1517/14622416.5.4.395
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A broad range of genomics and proteomics technologies are increasingly being integrated into emerging research fields such as pharmacogenomics, pharmacoproteomics, chemogenomics, chemical genetics, and chemical biology. Here we review applications of genomic and proteomic technologies to drug mechanism-of-action studies and how these are beginning to impact the drug discovery process.
引用
收藏
页码：395 / 404
页数：10
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