DAX-1 expression in human breast cancer:: comparison with estrogen receptors ER-α, ER-β and androgen receptor status

被引:33
作者
Conde, I
Alfaro, JM
Fraile, B
Ruíz, A
Paniagua, R
Arenas, MI [1 ]
机构
[1] Univ Alcala de Henares, Dept Cell Biol & Genet, Madrid 28871, Spain
[2] Hosp Principe Asturias, Dept Pathol, Madrid, Spain
关键词
androgen receptor; breast cancer; DAX-1; estrogen receptor-alpha; estrogen receptor-beta;
D O I
10.1186/bcr766
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: So far there have been no reports on the expression pattern of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) in human breast cells and its relationship to the estrogen receptors, ER-alpha and ER-beta, and the androgen receptor (AR). Methods: In this study we evaluated, by immunohistochemistry and Western blot analysis, the presence and distribution of DAX-1 in benign breast disease (BBD), in situ carcinoma (CIS), and ductal and lobular breast carcinomas. Results: In BBD and breast carcinomas, DAX-1 was present in both the nuclei and the cytoplasm of epithelial cells, although in infiltrative carcinomas the percentage of nuclear immunoreaction was higher than in CIS. An important relation was observed between DAX-1 and AR expression and between this orphan receptor and nodal status. Conclusion: DAX-1 might modify the AR and ER-beta intracellular location, and because a direct positive relation between the expression of these three receptors was found it could be assumed that the presence of DAX-1 in neoplastic cells might indicate a possible failure of endocrine therapies.
引用
收藏
页码:R140 / R148
页数:9
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