Importance of clonal hematopoiesis in heart failure

被引：9

作者：

Chavkin, Nicholas W. ^{[1
,2
,3
]}

Min, Kyung-Duk ^{[1
,2
,3
]}

Walsh, Kenneth ^{[1
,2
,3
]}

机构：

[1] Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

[2] Dept Cardiol, Charlottesville, VA 22908 USA

[3] Univ Virginia, Sch Med, Hematovasc Biol Ctr, Charlottesville, VA 22908 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2022年 / 32卷 / 04期

关键词：

Clonal hematopoiesis; Heart failure; Inflammation; CIRCULATING LEVELS; RISK; DISEASE; TET2; INFLAMMATION; CHROMATIN; EXPANSION; CYTOKINES; PROTEINS; FIBROSIS;

D O I：

10.1016/j.tcm.2021.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is prevalent in the elderly population. Inflammatory processes can contribute to the progression of heart failure by altering the balance of tissue healing and pathological remodeling during the injury response. New findings show that aging can alter immune cell phenotypes through the process of clonal hematopoiesis. This condition results from acquired somatic DNA mutations in specific driver genes that give rise to clonal expansions of mutant hematopoietic cells with overactive inflammatory properties. Recent clinical and experimental studies have shown that clonal hematopoiesis is prevalent in heart failure patients and associated with poor prognosis. In this review, we summarize current evidence that associates clonal hematopoiesis with the progression of heart failure. We further describe the mechanistic links between clonal hematopoiesis and the pro-inflammatory responses that can contribute to pathological outcomes in the heart. Finally, we provide perspectives on future research directions in the area of clonal hematopoiesis and heart failure. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：198 / 203

页数：6

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