pH-Induced In Situ Gel for Periodontal Anesthesia

被引：2

作者：

Gupta, H. ^{[1
]}

Singh, R. M. ^{[1
]}

Singh, G. N. ^{[1
]}

Kaushik, D. ^{[2
]}

Sharma, A. ^{[2
]}

机构：

[1] Cent Indian Pharmacopoeia Lab, Raj Nagar 201002, Ghaziabad, India

[2] Kurukshetra Univ, Univ Inst Pharmaceut Sci, Kurukshetra 132119, Haryana, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 70卷 / 06期

关键词：

In situ gel; periodontal anaesthesia; prilocaine hydrochloride;

D O I：

10.4103/0250-474X.49120

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelation pH, viscosity, physicochemical properties, in vitro release, sterility and stability. Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.

引用

页码：776 / 778

页数：3

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