Isocarbostyril alkaloids and their derivatives as promising antitumor agents

被引：1
作者：
Ji, Yu-bin [1 ]
Zheng, Jia [1 ]
Chen, Ning [1 ]
Song, Dong-xue [1 ]
Dong, Yan [1 ]
Wang, Bai-feng [1 ]
机构：
[1] Harbin Univ Commerce, Minist Educ, Engn Res Ctr Nat Anticanc Drugs, Harbin 150076, Peoples R China
来源：
INFORMATION TECHNOLOGY APPLICATIONS IN INDUSTRY II, PTS 1-4 | 2013年 / 411-414卷
关键词：
Isocarbostyril; narciclasine; lycoricidine; pancratistatin; derivatives; antineoplastic; AMARYLLIDACEAE; NARCICLASINE; APOPTOSIS; CANCER; CELLS;
D O I：
10.4028/www.scientific.net/AMM.411-414.3150
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
Isocarbostyril alkaloids is a kind of alkaloid does not contain basic nitrogen atoms and is represented by hydroxylated benzophenanthridone or isoquinolinone types of structure. The most widely known compounds of this group are narciclasine, lycoricidine, and pancratistatin. They have demonstrated to inhibite the proliferation of many human cancer cells, and at the same time have no affect on normal human cells under a certain dose, they have a high efficiency and low toxicity in antitumor area. Now this kind of compound has been a hot spot research to antitumor workers. The present paper reviews the origin and the antitumor function of the Isocarbostyril alkaloids.
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页码：3150 / 3153
页数：4
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