Heliotropium bacciferum Forssk. (Boraginaceae) extracts: chemical constituents, antioxidant activity and cytotoxic effect in human cancer cell lines

被引：34

作者：

Aissaoui, Hanane ^{[1
]}

Mencherini, Teresa ^{[2
]}

Esposito, Tiziana ^{[2
,3
]}

De Tommasi, Nunziatina ^{[2
]}

Gazzerro, Patrizia ^{[2
]}

Benayache, Samir ^{[1
]}

Benayache, Fadila ^{[1
]}

Mekkiou, Ratiba ^{[1
]}

机构：

[1] Univ Freres Mentouri, Unite Rech Valorisat Ressources Nat & Anal Physch, Constantine, Algeria

[2] Univ Salerno, Dipartimento Farm, Fisciano, Italy

[3] Univ Salerno, Program Drug Discovery & Dev, Fisciano, Italy

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 12期

关键词：

Heliotropium bacciferum; Boraginaceae; terpenoids; polyphenols; antioxidant activity; cytotoxic effect; MONOTERPENE GLUCOSIDE;

D O I：

10.1080/14786419.2018.1437433

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Heliotropium bacciferum (Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it is traditionally used for skin diseases and tonsillitis. Herein, we report the isolation and characterization of sixteen secondary metabolites from the aerial part extracts. They include a sterol (1), megastigman type nor-isoprenoids (2, 3, 4, 6, 8, 10), C-11 terpene lactones (5 and 9), and a monoterpene (7) from the chloroform extract (HB-C); monoterpene glucoside (14), and phenolic compounds (11-13, 15, 16) from the methanol one (HB-M). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, and ESIMS analysis. HB-M showed a significant and concentration dependent scavenging activity in vitro against the radicals DPPH and ABTS, related to the phenol derivatives (11-13, and 15-16), and HB-C inhibited the growth of colon cancer cell lines, mainly for the presence of the antiproliferative C-11 terpene lactones (5 and 9). [GRAPHICS] .

引用

页码：1813 / 1818

页数：6

共 23 条

[1] Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae) [J].

Abedini, Amin ;

Roumy, Vincent ;

Mahieux, Severine ;

Biabiany, Murielle ;

Standaert-Vitse, Annie ;

Riviere, Celine ;

Sahpaz, Sevser ;

Bailleul, Francois ;

Neut, Christel ;

Hennebelle, Thierry .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013

[2]

Ahmad S., 2014, The Scientific World Journal, P1, DOI [DOI 10.1155/2014/561539, 10.1155/2014/561539]

[3] In Vitro Antimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis of Heliotropium bacciferum [J].

Ahmad, Sohail ;

AbdEl-Salam, Naser M. ;

Ullah, Riaz .

BIOMED RESEARCH INTERNATIONAL, 2016, 2016

[4]

Amen Y. M., 2013, The Journal of American Science, V9, P334

[5]

[Anonymous], J PHARM SCI

[6] Norsesquiterpenoids from the leaves of Croton tiglium [J].

Bu W. ;

Shi Y.-N. ;

Yan Y.-M. ;

Lu Q. ;

Liu G.-M. ;

Li Y. ;

Cheng Y.-X. .

Natural Products and Bioprospecting, 2011, 1 (3) :134-137

[7] Androstane and monoterpene glucoside sinapoyl ester from Cynanchum amplexicaule SIEB. et Zucc. [J].

Chen, Huan ;

Zhou, Yu-Zhi ;

Qiao, Li ;

Cao, Jia-Qing ;

Yao, Yao ;

Hua, Hui-Ming ;

Pei, Yue-Hu .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (09) :1416-1418

[8]

Erosa-Rejón G, 2009, J MEX CHEM SOC, V53, P44

[9] Pyrrolizidine alkaloids of Heliotropium bacciferum Forssk from Egypt [J].

Farrag, NM ;

AbdelAziz, EM ;

ElShafae, AM ;

Ateya, AM ;

ElDomiaty, MM .

INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1996, 34 (05) :374-377

[10] ISOLATION OF R-(-)-3-HYDROXY-BETA-IONONE FROM BURLEY TOBACCO [J].

FUJIMORI, T ;

KASUGA, R ;

NOGUCHI, M ;

KANEKO, H .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1974, 38 (04) :891-892

← 1 2 3 →