Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

被引：91

作者：

Vatanen, Tommi ^{[1
,2
,3
]}

Jabbar, Karolina S. ^{[1
]}

Ruohtula, Terhi ^{[4
]}

Honkanen, Jarno ^{[4
]}

Avila-Pacheco, Julian ^{[1
]}

Siljander, Heli ^{[4
,5
]}

Strazar, Martin ^{[1
]}

Oikarinen, Sami ^{[6
]}

Hyoty, Heikki ^{[6
,7
]}

Ilonen, Jorma ^{[8
]}

Mitchell, Caroline M. ^{[9
]}

Yassour, Moran ^{[10
,11
]}

Virtanen, Suvi M. ^{[12
,13
,14
,15
]}

Clish, Clary B. ^{[1
]}

Plichta, Damian R. ^{[1
,16
]}

Vlamakis, Hera ^{[1
,16
]}

Knip, Mikael ^{[2
,4
,17
]}

Xavier, Ramnik J. ^{[1
,16
,18
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland

[3] Univ Auckland, Liggins Inst, Auckland, New Zealand

[4] Helsinki Univ Hosp, New Childrens Hosp, Helsinki, Finland

[5] Finnish Def Forces, Ctr Mil Med, Riihimaki, Finland

[6] Tampere Univ, Fac Med & Hlth Technol, Dept Virol, Tampere, Finland

[7] Fimlab Labs, Tampere, Finland

[8] Univ Turku, Inst Biomed, Immunogenet Lab, Turku, Finland

[9] Massachusetts Gen Hosp, Vincent Obstet & Gynecol Dept, Boston, MA 02114 USA

[10] Hebrew Univ Jerusalem, Fac Med, Microbiol & Mol Genet Dept, Jerusalem, Israel

[11] Hebrew Univ Jerusalem, Rachel & Selim Benin Sch Comp Sci & Engn, Jerusalem, Israel

[12] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

[13] Tampere Univ, Fac Social Sci, Unit Hlth Sci, Tampere, Finland

[14] Tampere Univ Hosp, Ctr Child Hlth Res & Dev, Tampere, Finland

[15] Tampere Univ Hosp, Innovat Ctr, Tampere, Finland

[16] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[17] Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere, Finland

[18] Harvard Med Sch, Massachusetts Gen Hosp, Dept Mol Biol, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

来源：

CELL | 2022年 / 185卷 / 26期

基金：

美国国家卫生研究院;

关键词：

INTESTINAL PERMEABILITY; HUMAN BETA-DEFENSIN-2; MASS-SPECTROMETRY; BREAST-MILK; TRANSMISSION; INFLAMMATION; DIVERSITY; GROWTH; 1ST;

D O I：

10.1016/j.cell.2022.11.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The perinatal period represents a critical window for cognitive and immune system development, promoted by maternal and infant gut microbiomes and their metabolites. Here, we tracked the co-development of mi-crobiomes and metabolomes from late pregnancy to 1 year of age using longitudinal multi-omics data from a cohort of 70 mother-infant dyads. We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations. Infant gut metabo-lomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. Metabolomes and serum cytokine signatures of infants who received regular-but not extensively hydrolyzed-formula were distinct from those of exclusively breastfed infants. Taken together, our integrative analysis expands the concept of vertical transmission of the gut microbiome and provides original insights into the development of maternal and infant microbiomes and metabolomes during late pregnancy and early life.

引用

页码：4921 / +

页数：32

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