The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases

被引：128

作者：

Wang, Xiaoyu ^{[1
]}

Zhou, Yunxiang ^{[2
]}

Gao, Qiannan ^{[3
]}

Ping, Dongnan ^{[4
]}

Wang, Yali ^{[2
]}

Wu, Wei ^{[5
]}

Lin, Xu ^{[5
]}

Fang, Yuanjian ^{[1
]}

Zhang, Jianmin ^{[1
]}

Shao, Anwen ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou 310009, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Oncol, Hangzhou 310009, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

[4] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷

基金：

中国国家自然科学基金;

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; MITOCHONDRIAL-DNA DELETIONS; ALZHEIMERS-DISEASE; EXTRACELLULAR VESICLES; PARKINSONS-DISEASE; SERUM EXOSOME; HUNTINGTONS-DISEASE; GLUCOSE DEPRIVATION; FUNCTIONAL RECOVERY; COGNITIVE DEFICITS;

D O I：

10.1155/2020/3232869

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neurodegenerative diseases including Alzheimer's disease and Parkinson's disease are aging-associated diseases with irreversible damage of brain tissue. Oxidative stress is commonly detected in neurodegenerative diseases and related to neuronal injury and pathological progress. Exosome, one of the extracellular vesicles, is demonstrated to carry microRNAs (miRNAs) and build up a cell-cell communication in neurons. Recent research has found that exosomal miRNAs regulate the activity of multiple physiological pathways, including the oxidative stress response, in neurodegenerative diseases. Here, we review the role of exosomal miRNAs and oxidative stress in neurodegenerative diseases. Firstly, we explore the relationship between oxidative stress and neurodegenerative diseases. Secondly, we introduce the characteristics of exosomes and roles of exosome-related miRNAs. Thirdly, we summarized the crosstalk between exosomal miRNAs and oxidative stress in neurodegenerative diseases. Fourthly, we discuss the potential of exosomes to be a biomarker in neurodegenerative diseases. Finally, we summarize the advantages of exosome-based delivery and present situation of research on exosome-based delivery of therapeutic miRNA. Our work is aimed at probing and reinforcing the recognition of the pathomechanism of neurodegenerative diseases and providing the basis for novel strategies of clinical diagnosis and treatment.

引用

页数：17

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