Binding of actinomycin D to single-stranded DNA

被引：10
作者：
JaresErijman, EA
Klement, R
Machinek, R
Wadkins, RM
Kankia, BI
Marky, LA
Jovin, TM
机构：
[1] MAX PLANCK INST BIOPHYS CHEM,DEPT MOL BIOL,D-37018 GOTTINGEN,GERMANY
[2] UNIV GOTTINGEN,INST ORGAN CHEM,D-3400 GOTTINGEN,GERMANY
[3] NYU,DEPT CHEM,NEW YORK,NY 10003
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 5-6期
关键词：
D O I：
10.1080/07328319708002931
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sequence specificity and structural aspects of the mode of interaction of the antitumor drug actinomycin D (AMD) with single-stranded DNA were studied by fluorescence, absorption and NMR spectroscopy, calorimetry, ultrasonic velocity and density measurements, and molecular modeling. The binding is length and sequence dependent, with the tetranucleotide motif TAGT showing the highest affinity. A ''hemi-intercalation'' model for the interaction is proposed.
引用
收藏
页码：661 / 667
页数：7
相关论文
共 23 条
[1]   FORMATION OF MULTIPLE COMPLEXES BETWEEN ACTINOMYCIN-D AND A DNA HAIRPIN - STRUCTURAL CHARACTERIZATION BY MULTINUCLEAR NMR [J].
BROWN, DR ;
KURZ, M ;
KEARNS, DR ;
HSU, VL .
BIOCHEMISTRY, 1994, 33 (03) :651-664
[2]   EFFECT OF ACTINOMYCIN-D ON NUCLEIC-ACID HYBRIDIZATION - THE CAUSE OF ERRONEOUS DNA ELONGATION DURING DNA-SYNTHESIS OF RNA TUMOR-VIRUSES INVITRO [J].
BUNTE, T ;
NOVAK, U ;
FRIEDRICH, R ;
MOELLING, K .
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 610 (02) :241-247
[3]   REASSESSMENT OF STRUCTURAL CHARACTERISTICS OF THE D(CGCG)2 - ACTINOMYCIN-D COMPLEX FROM COMPLETE H-1 AND P-31 NMR [J].
DELEPIERRE, M ;
VANHEIJENOORT, C ;
IGOLEN, J ;
POTHIER, J ;
LEBRET, M ;
ROQUES, BP .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1989, 7 (03) :557-589
[4]   P-31 AND 2-DIMENSIONAL P-31-H-1 CORRELATED NMR-SPECTRA OF DUPLEX D(AP[O-17]GP[O-18]CP[O-16]T) AND ASSIGNMENT OF P-31 SIGNALS IN D(APGPCPT)2 ACTINOMYCIN-D COMPLEX [J].
GORENSTEIN, DG ;
LAI, K ;
SHAH, DO .
BIOCHEMISTRY, 1984, 23 (26) :6717-6723
[5]   REASSOCIATION RATE LIMITED DISPLACEMENT OF DNA-STRANDS BY BRANCH MIGRATION [J].
GREEN, C ;
TIBBETTS, C .
NUCLEIC ACIDS RESEARCH, 1981, 9 (08) :1905-1918
[6]   STUDIES OF NONCOVALENT INTERACTIONS OF ACTINOMYCIN-D WITH SINGLE-STRANDED OLIGODEOXYNUCLEOTIDES BY ION-SPRAY MASS-SPECTROMETRY AND TANDEM MASS-SPECTROMETRY [J].
HSIEH, YL ;
LI, YT ;
HENION, JD ;
GANEM, B .
BIOLOGICAL MASS SPECTROMETRY, 1994, 23 (05) :272-276
[7]  
JARESERIJMAN EA, UNPUB
[8]   AN NMR INVESTIGATION OF THE BINDING OF THE ANTICANCER DRUG ACTINOMYCIN-D TO OLIGODEOXYRIBONUCLEOTIDES WITH ISOLATED 5'D(GC)3' BINDING-SITES [J].
JONES, RL ;
SCOTT, EV ;
ZON, G ;
MARZILLI, LG ;
WILSON, WD .
BIOCHEMISTRY, 1988, 27 (16) :6021-6026
[9]  
KANKIA BI, UNPUB
[10]  
LIU X, 1991, Journal of Biomolecular NMR, V1, P323, DOI 10.1007/BF02192858
123