Tumor size and focality in breast carcinoma: Analysis of concordance between radiological imaging modalities and pathological examination at a cancer center

被引:7
作者
Guadalupe, Lorena Di Pasquale [1 ,3 ]
Jesus, Jose De [1 ,4 ]
Xiong, Yin [2 ]
Rosa, Marilin [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Clin Sci Lab, Tampa, FL USA
[3] Puerto Rico Pathol, 198 Calle Trinidad, San Juan, PR 00917 USA
[4] Hato Rey Pathol Associates, 300 Calle Domenech, San Juan, PR 00918 USA
关键词
Breast carcinoma; Pathological radiological correlation; Tumor size; Tumor stage; MAMMOGRAPHY; ACCURACY; MRI; EFFICACY; US;
D O I
10.1016/j.anndiagpath.2020.151601
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Context Accurate assessment of clinical and pathological tumor stage is crucial for patient treatment and prognosis. Objective: The aim of this study was to assess the concordance between the tumor size and focality between radiological studies and pathology and to evaluate the impact of discrepancies on staging. Design: Patients who underwent surgery for invasive breast carcinoma from January 1, 2014, to December 31, 2015, were identified. Results: Three imaging modalities (mammogram, ultrasound and MRI) were compared with gross examination and final pathology. 1152 preoperative radiological studies were evaluated for focality and 1019 were evaluated for tumor size. For all 3 radiographic modalities, there was a statistically significant difference between the mean tumor size on radiology and the final pathology report (mammogram, P < .001; ultrasound, P = .004; MRI, P < .001). In 29% of radiology studies, there was a discrepancy in stage. The error rate for determining focality was 28% for mammograms, 27% for ultrasounds, and 29% for MRIs. Tumor size from gross examination correlated with microscopic tumor size in 57% of cases, but gross examination had 88% concordance with the final pathology report in determining focality. Conclusion: Our study revealed statistically significant differences in mean tumor size reported across all 3 imaging modalities when compared to the final pathology report. MRI had the highest error rate, with a tendency to overestimate tumor size and number of foci. Among all diagnoses, cases of invasive carcinoma with an extensive intraductal component were most prone to discrepancies with imaging.
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页数:7
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共 36 条
[1]  
Abner AL, 1998, CANCER-AM CANCER SOC, V83, P2502, DOI 10.1002/(SICI)1097-0142(19981215)83:12<2502::AID-CNCR14>3.0.CO
[2]  
2-I
[3]  
[Anonymous], 2018, APPL CANC RES
[4]  
[Anonymous], 2017, PRACT GUID ONC BREAS
[5]  
[Anonymous], 2018, AJCC CANC STAGING MA
[6]  
Behjatnia B, 2010, INT J CLIN EXP PATHO, V3, P303
[7]   Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer [J].
Berg, WA ;
Gutierrez, L ;
NessAiver, MS ;
Carter, WB ;
Bhargavan, M ;
Lewis, RS ;
Ioffe, OB .
RADIOLOGY, 2004, 233 (03) :830-849
[8]   The efficacy of breast MRI in predicting breast conservation therapy [J].
Blair, Sarah ;
Mcelroy, Michele ;
Middleton, Michael S. ;
Comstock, Chris ;
Wolfson, Tanya ;
Kamrava, Mitch ;
Wallace, Anne ;
Mortimer, Joanne .
JOURNAL OF SURGICAL ONCOLOGY, 2006, 94 (03) :220-225
[9]   BREAST-TUMORS - COMPARATIVE ACCURACY OF MR-IMAGING RELATIVE TO MAMMOGRAPHY AND US FOR DEMONSTRATING EXTENT [J].
BOETES, C ;
MUS, RDM ;
HOLLAND, R ;
BARENTSZ, JO ;
STRIJK, SP ;
WOBBES, T ;
HENDRIKS, JHCL ;
RUYS, SHJ .
RADIOLOGY, 1995, 197 (03) :743-747
[10]   Relevance of breast MRI in determining the size and focality of invasive breast cancer treated by mastectomy: a prospective study [J].
Carin, Anne-Julie ;
Moliere, Sebastien ;
Gabriele, Victor ;
Lodi, Massimo ;
Thiebaut, Nicolas ;
Neuberger, Karl ;
Mathelin, Carole .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2017, 15