RETRACTED: Brain hydrogen sulfide is severely decreased in Alzheimer's disease (Retracted Article)

被引:740
作者
Eto, K
Asada, T
Arima, K
Makifuchi, T
Kimura, H
机构
[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Kodaira, Tokyo 1878551, Japan
[2] Natl Ctr Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorders, Kodaira, Tokyo 1878551, Japan
[3] Natl Saigata Hosp, Niigata 9493193, Japan
关键词
hydrogen sulfide; Alzheimer's disease; cystathionine beta-synthase; brain; S-Adenosyl-L-methionine; homocysteine; cysteine;
D O I
10.1016/S0006-291X(02)00422-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS). H2S functions as a neuromodulator as well Lis a smooth muscle relaxant. Here we show that the levels of HS are severely decreased in the brains of Alzheimer's disease (AD) patients compared with the brains of the age matched normal individuals. In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine. Previous findings, which showed that S-adenosyl-L-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed. These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:1485 / 1488
页数:4
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