Comparative studies on the mechanism of action of serotonin in frog, rat and human adrenocortical cells

被引：0

作者：

Lenglet, S ^{[1
]}

Delarue, C ^{[1
]}

Louiset, E ^{[1
]}

Vaudry, H ^{[1
]}

Contesse, V ^{[1
]}

机构：

[1] Univ Rouen, CNRS, INSERM,European Inst Peptide Res,IFRMP 23, U413,UA,Lab Cellular & Mol Neuroendocrinol, F-76821 Mont St Aignan, France

来源：

PERSPECTIVE IN COMPARATIVE ENDOCRINOLOGY: UNITY AND DIVERSITY | 2001年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serotonin (5-HT) is a potent stimulator of corticosteroid secretion in amphibians and mammals, but the effects of 5-HT appear to be mediated by different receptor subtypes, i.e. 5-HT4 receptors in frog and human, and 5-HT7 receptors in rat. The aim of the present study was to determine the transduction mechanisms associated with activation of the different 5-HT receptor subtypes in frog, rat and human adrenocortical cells. In the three species, 5-HT induced a significant increase in cAMP formation by adrenal fragments. The application of 5-HT in the vicinity of cultured frog, rat or human adrenocortical cells also caused a substantial increase in [Ca2+](i). The involvement of CAMP and calcium rise in the mechanism of action of 5-HT was studied on perifused frog and rat adrenal slices. In both species, the agonist-induced aldosterone secretion was significantly reduced in the presence of PKA inhibitors or in Ca2+-depleted medium. These data demonstrate that, while the types of adrenal serotonergic receptors differ from one species to the other, the mechanism of action of 5-HT on adrenocortical cells has been conserved during evolution.

引用

页码：1257 / 1261

页数：5

共 6 条

[1] Pharmacological and molecular characterization of 5-hydroxytryptamine7 receptors in the rat adrenal gland [J].