Molecular biology of reproduction and development in parasitic nematodes: progress and opportunities

被引:33
作者
Nisbet, AJ [1 ]
Cottee, P [1 ]
Gasser, RB [1 ]
机构
[1] Univ Melbourne, Dept Vet Sci, Werribee, Vic 3030, Australia
基金
澳大利亚研究理事会;
关键词
gender; reproduction; development; spermatogenesis; exsheathment; oogenesis;
D O I
10.1016/j.ijpara.2003.09.012
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Molecular biological research on the development and reproduction of parasites is of major significance for many fundamental and applied areas of medical and veterinary parasitology. Together with knowledge of parasite biology and epidemiology, the application of molecular tools and technologies provides unique opportunities for elucidating developmental and reproductive processes in helminths. This article focuses specifically on recent progress in studying the molecular mechanisms of development, sexual differentiation and reproduction in parasitic nematodes of socio-economic importance and comparative analyses, where appropriate, with the free-living nematode Caenorhabditis elegans. It also describes the implications of such work for understanding reproduction, tissue migration, hypobiosis, signal transduction and host-parasite interactions at the molecular level, and for seeking new means of parasite intervention. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:125 / 138
页数:14
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