A ruthenium(ii)-catalyzed C-H allenylation-based approach to allenoic acids

被引：34

作者：

Wu, Xiaoyan ^{[1
]}

Fan, Junjie ^{[1
]}

Fu, Chunling ^{[1
]}

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHEMICAL SCIENCE | 2019年 / 10卷 / 25期

基金：

中国国家自然科学基金;

关键词：

2,3-ALLENOIC ACIDS; ENANTIOSELECTIVE SYNTHESIS; BOND FUNCTIONALIZATIONS; CYCLIZATION REACTIONS; EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; NATURAL-PRODUCTS; DIRECTING GROUPS; ARYLATION; COUPLING/CYCLIZATION;

D O I：

10.1039/c9sc00603f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Ru(ii)-catalyzed direct access to various functionalized allenoic acids via C-H allenylation of readily available aryl carboxylic acids with propargylic acetates is reported. Axially chiral allenoic acids could be obtained in high ee by using optically active propargylic acetates through a chirality transfer strategy.

引用

页码：6316 / 6321

页数：6

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