Gut Microbiota and Response to Immunotherapeutic Drugs in Oncology: More Questions Than Answers

被引：2

作者：

Abhyankar, Dhiraj ^{[1
]}

McKee, Kelly T., Jr. ^{[1
]}

Vukojevic, Pavle ^{[1
]}

机构：

[1] Pharm Olam LLC, 79 TW Alexander Dr,Bldg 4401,Suite 240, Durham, NC 27709 USA

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2020年 / 14卷

关键词：

Immuno-oncology drugs; cancer; gut microbiome; gut microorganisms; gut microbiota; IOD response; anti-PD-1; therapy; PD-L1; tumor growth; fecal microbiota transplant process; bacteria; immune checkpoint inhibitors;

D O I：

10.1177/1179554920933868

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immuno-oncology drugs (IODs) have revolutionized the treatment of some cancers. Although IODs are enabling some patients with cancer to become long-time survivors, only 30% to 40% respond to these drugs. There is experimental and clinical evidence that the gut microbiome may play a role in IOD response, leading to speculation that manipulation of the gut microenvironment might improve the response rate to IODs. We review the evidence relating to how gut microorganisms may affect response to IODs and discuss the implications of targeting the microbiome to improve IOD response, including the challenges to refine and translate the findings to practical clinical use.

引用

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