The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control

被引:34
|
作者
Shilo, Smadar [1 ,2 ,3 ]
Godneva, Anastasia [1 ,2 ]
Rachmiel, Marianna [4 ,5 ]
Korem, Tal [1 ,2 ,6 ]
Bussi, Yuval [1 ,2 ]
Kolobkov, Dmitry [1 ,2 ]
Karady, Tal [1 ,2 ]
Bar, Noam [1 ,2 ]
Wolf, Bat Chen [1 ,2 ]
Glantz-Gashai, Yitav [3 ]
Cohen, Michal [3 ,7 ]
Levin, Nehama Zuckerman [3 ,7 ]
Shehadeh, Naim [3 ,7 ]
Gruber, Noah [5 ,8 ]
Levran, Neriya [8 ,9 ]
Koren, Shlomit [5 ,10 ]
Weinberger, Adina [1 ,2 ]
Pinhas-Hamiel, Orit [5 ,8 ]
Segal, Eran [1 ,2 ]
机构
[1] Weizmann Inst Sci, Dept Comp Sci & Appl Math, Rehovot, Israel
[2] Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel
[3] Rambam Hlth Care Campus, Inst Diabet Endocrinol & Metab, Pediat Diabet Clin, Haifa, Israel
[4] Shamir Med Ctr, Pediat Endocrinol Unit, Zerifin, Israel
[5] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
[6] Columbia Univ, Dept Syst Biol, New York, NY USA
[7] Technion, Bruce Rappaport Fac Med, Haifa, Israel
[8] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Pediat Endocrine & Diabet Unit, Ramat Gan, Israel
[9] Hebrew Univ Jerusalem, Robert H Smith Fac Agr Food & Environm, Rehovot, Israel
[10] Shamir Med Ctr, Diabet Unit, Zerifin, Israel
基金
以色列科学基金会; 欧洲研究理事会;
关键词
INTESTINAL MICROBIOTA; DYNAMICS; GERMANY; ONSET;
D O I
10.2337/dc21-1656
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE Previous studies have demonstrated an association between gut microbiota composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the composition and function of the gut microbiome in adults with longstanding T1D or its association with host glycemic control. RESEARCH DESIGN AND METHODS We performed a metagenomic analysis of the gut microbiome obtained from fecal samples of 74 adults with T1D, 14.6 9.6 years following diagnosis, and compared their microbial composition and function to 296 age-matched healthy control subjects (1:4 ratio). We further analyzed the association between microbial taxa and indices of glycemic control derived from continuous glucose monitoring measurements and blood tests and constructed a prediction model that solely takes microbiome features as input to evaluate the discriminative power of microbial composition for distinguishing individuals with T1D from control subjects. RESULTS Adults with T1D had a distinct microbial signature that separated them from control subjects when using prediction algorithms on held-out subjects (area under the receiver operating characteristic curve = 0.89 +/- 0.03). Linear discriminant analysis showed several bacterial species with significantly higher scores in T1D, including Prevotella copri and Eubacterium siraeum, and species with higher scores in control subjects, including Firmicutes bacterium and Faecalibacterium prausnitzii (P < 0.05, false discovery rate corrected for all). On the functional level, several metabolic pathways were significantly lower in adults with T1D. Several bacterial taxa and metabolic pathways were associated with the host's glycemic control. CONCLUSIONS We identified a distinct gut microbial signature in adults with longstanding T1D and associations between microbial taxa, metabolic pathways, and glycemic control indices. Additional mechanistic studies are needed to identify the role of these bacteria for potential therapeutic strategies.
引用
收藏
页码:555 / 563
页数:9
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