Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)-H Bond Alkenylation by Alkynes

被引：435
作者：
Grigorjeva, Liene [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 38期
关键词：
alkenes; alkynes; C-H activation; cobalt; cyclization; C-H BOND; UNACTIVATED C(SP(3))-H BONDS; BIDENTATE-CHELATION ASSISTANCE; CARBON-HYDROGEN BONDS; DIRECT ALKYNYLATION; TERMINAL ALKYNES; EFFICIENT SYNTHESIS; ACID-DERIVATIVES; AROMATIC AMIDES; ACTIVATION;
D O I：
10.1002/anie.201404579
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for cobalt-catalyzed, aminoquinoline-and picolinamide-directed C(sp(2))-H bond alkenylation by alkynes was developed. The method shows excellent functional-group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc)(2)center dot 4H(2)O catalyst, Mn(OAc)(2) co-catalyst, and oxygen (from air) as a terminal oxidant.
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页码：10209 / 10212
页数：4
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