Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)-H Bond Alkenylation by Alkynes

被引：445

作者：

Grigorjeva, Liene ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Houston, TX 77204 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 38期

关键词：

alkenes; alkynes; C-H activation; cobalt; cyclization; C-H BOND; UNACTIVATED C(SP(3))-H BONDS; BIDENTATE-CHELATION ASSISTANCE; CARBON-HYDROGEN BONDS; DIRECT ALKYNYLATION; TERMINAL ALKYNES; EFFICIENT SYNTHESIS; ACID-DERIVATIVES; AROMATIC AMIDES; ACTIVATION;

D O I：

10.1002/anie.201404579

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for cobalt-catalyzed, aminoquinoline-and picolinamide-directed C(sp(2))-H bond alkenylation by alkynes was developed. The method shows excellent functional-group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc)(2)center dot 4H(2)O catalyst, Mn(OAc)(2) co-catalyst, and oxygen (from air) as a terminal oxidant.

引用

页码：10209 / 10212

页数：4

共 78 条

[1] Ruthenium-Catalyzed Oxidative Annulation by Cleavage of C-H/N-H Bonds [J].