[3+2] Cycloaddition of para-Quinone Methides with Nitrile Imines: Approach to Spiro-pyrazoline-cyclohexadienones

被引：58

作者：

Su, Yingpeng ^{[1
]}

Zhao, Yanan ^{[1
]}

Chang, Bingbing ^{[1
]}

Zhao, Xiaolong ^{[1
]}

Zhang, Rong ^{[1
]}

Liu, Xuan ^{[1
]}

Huang, Danfeng ^{[1
]}

Wang, Ke-Hu ^{[1
]}

Huo, Congde ^{[1
]}

Hu, Yulai ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, 967 Anning East Rd, Lanzhou 730070, Gansu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITIONS; SPIROPYRAZOLINE OXINDOLES; SULFONIUM SALTS; ACCESS; NITRILIMINES; ANNULATION; SPIROCYCLOPROPANATION; PYRROLOIMINOQUINONE; DEAROMATIZATION; DERIVATIVES;

D O I：

10.1021/acs.joc.9b00434

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[3 + 2] cycloaddition of para-quinone methides with nitrile imines under mild conditions has been achieved. The corresponding spiro-pyrazoline-cyclohexadienone products were constructed in good to excellent yields (up to 97% yield) with high regioselectivity. This straightforward protocol exhibits good functional group tolerance and scalability and provides the spiro-pyrazoline-cydohexadienones.

引用

页码：6719 / 6728

页数：10

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