Helicobacter pylori, asthma and allergy

被引：41

作者：

D'Elios, Mario Milco ^{[1
,2
]}

Codolo, Gaia ^{[3
,4
]}

Amedei, Amedeo ^{[1
,2
]}

Mazzi, Paola ^{[5
]}

Berton, Giorgio ^{[5
]}

Zanotti, Giuseppe ^{[3
]}

Del Prete, Gianfranco ^{[1
,2
]}

de Bernard, Marina ^{[3
,4
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[2] AOUC Careggi, Dept Biomed, Florence, Italy

[3] Venetian Inst Mol Med, Padua, Italy

[4] Univ Padua, Dept Biol, Padua, Italy

[5] Univ Verona, Dept Pathol, Sect Gen Pathol, I-37100 Verona, Italy

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2009年 / 56卷 / 01期

关键词：

Helicobacter pylori; asthma; allergy; cytokines; chemokines; immune modulation; NEUTROPHIL-ACTIVATING PROTEIN; CRYSTAL-STRUCTURE; T-CELLS; GASTRIC-MUCOSA; UP-REGULATION; TH1; INFLAMMATION; LINEAGE; BINDING; EXPRESSION;

D O I：

10.1111/j.1574-695X.2009.00537.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bronchial asthma and allergic diseases are orchestrated by T-cells producing T-helper type 2 (Th2) cytokines, such as interleukin-4 (IL-4) and IL-5, and are inhibited by Th1 responses. Helicobacter pylori has chronically infected the human population for c. 100000 years and preferentially elicits a Th1 mucosal immune response with the production of interferon-gamma and IL-12. Among several bacterial factors, the neutrophil-activating protein of H. pylori (HP-NAP) not only plays a key role in driving Th1 inflammation but it is also able to inhibit Th2 responses in vitro and in vivo in allergic bronchial asthma, in humans and mice. Both systemic and mucosal administrations of HP-NAP are successful in reducing eosinophilia, immunoglobulin E and systemic Th2 cytokines at the bronchial level. Thus, these results identify HP-NAP as a candidate for novel strategies for the prevention and treatment of allergic diseases.

引用

页码：1 / 8

页数：8

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