Neural innervation of white adipose tissue and the control of lipolysis

被引：236
作者：
Bartness, Timothy J. [1 ,2 ]
Liu, Yang [1 ,2 ,3 ]
Shrestha, Yogendra B. [3 ]
Ryu, Vitaly [1 ,2 ,3 ]
机构：
[1] Georgia State Univ, Dept Biol, Ctr Obes Reversal, Atlanta, GA 30302 USA
[2] Georgia State Univ, Ctr Behav Neurosci, Atlanta, GA 30302 USA
[3] NIDDK, Metab Dis Branch, NIH, Bethesda, MD 20892 USA
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2014年 / 35卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Pseudorabies virus; Herpes simplex virus-1; Siberian hamsters; Rats; Mice; Humans; Denervation; Norepinephrine turnover; Insulin; Leptin; SYMPATHETIC-NERVOUS-SYSTEM; HORMONE-SENSITIVE LIPASE; HEART-RATE-VARIABILITY; ATRIAL-NATRIURETIC-PEPTIDE; BETA-ADRENERGIC-RECEPTORS; SHORT-DAY RESPONSES; FAT-CELL LIPOLYSIS; CENTRAL SENSORY CIRCUITS; VAGAL AFFERENT-FIBERS; GENE-RELATED PEPTIDE;
D O I：
10.1016/j.yfrne.2014.04.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS-norepinephrine (NE)-mediated WAT lipolysis is dependent on beta-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific preventing generalizations among WAT depots and non-WAT organs. Leptin-triggered SNS-mediated lipolysis is weakly supported, whereas insulin or adenosine inhibition of SNS/NE-mediated lipolysis is strongly supported. In addition to lipolysis control, increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively. WAT sensory nerves are of spinal-origin and sensitive to local leptin and increases in sympathetic drive, the latter implicating lipolysis. Transsynaptic viral tract tracers revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：473 / 493
页数：21
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