Neural innervation of white adipose tissue and the control of lipolysis

被引：249

作者：

Bartness, Timothy J. ^{[1
,2
]}

Liu, Yang ^{[1
,2
,3
]}

Shrestha, Yogendra B. ^{[3
]}

Ryu, Vitaly ^{[1
,2
,3
]}

机构：

[1] Georgia State Univ, Dept Biol, Ctr Obes Reversal, Atlanta, GA 30302 USA

[2] Georgia State Univ, Ctr Behav Neurosci, Atlanta, GA 30302 USA

[3] NIDDK, Metab Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2014年 / 35卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Pseudorabies virus; Herpes simplex virus-1; Siberian hamsters; Rats; Mice; Humans; Denervation; Norepinephrine turnover; Insulin; Leptin; SYMPATHETIC-NERVOUS-SYSTEM; HORMONE-SENSITIVE LIPASE; HEART-RATE-VARIABILITY; ATRIAL-NATRIURETIC-PEPTIDE; BETA-ADRENERGIC-RECEPTORS; SHORT-DAY RESPONSES; FAT-CELL LIPOLYSIS; CENTRAL SENSORY CIRCUITS; VAGAL AFFERENT-FIBERS; GENE-RELATED PEPTIDE;

D O I：

10.1016/j.yfrne.2014.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS-norepinephrine (NE)-mediated WAT lipolysis is dependent on beta-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific preventing generalizations among WAT depots and non-WAT organs. Leptin-triggered SNS-mediated lipolysis is weakly supported, whereas insulin or adenosine inhibition of SNS/NE-mediated lipolysis is strongly supported. In addition to lipolysis control, increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively. WAT sensory nerves are of spinal-origin and sensitive to local leptin and increases in sympathetic drive, the latter implicating lipolysis. Transsynaptic viral tract tracers revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：473 / 493

页数：21

共 322 条

[1] Neurochemical Characterization and Sexual Dimorphism of Projections from the Brain to Abdominal and Subcutaneous White Adipose Tissue in the Rat [J].

Adler, Elaine S. ;

Hollis, Jacob H. ;

Clarke, Iain J. ;

Grattan, David R. ;

Oldfield, Brian J. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (45) :15913-15921

[2] An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81 [J].

Ahmed, Kashan ;

Tunaru, Sorin ;

Tang, Cong ;

Mueller, Michaela ;

Gille, Andreas ;

Sassmann, Antonia ;

Hanson, Julien ;

Offermanns, Stefan .

CELL METABOLISM, 2010, 11 (04) :311-319

[3] POWER SPECTRUM ANALYSIS OF HEART-RATE FLUCTUATION - A QUANTITATIVE PROBE OF BEAT-TO-BEAT CARDIOVASCULAR CONTROL [J].

AKSELROD, S ;

GORDON, D ;

UBEL, FA ;

SHANNON, DC ;

BARGER, AC ;

COHEN, RJ .

SCIENCE, 1981, 213 (4504) :220-222

[4] The use of short-term analysis of heart rate variability to assess autonomic function in obese children and its relationship with metabolic syndrome [J].

Altuncu, Mehmet Erkan ;

Baspinar, Osman ;

Keskin, Mehmet .

CARDIOLOGY JOURNAL, 2012, 19 (05) :501-506

[5] Natriuretic peptide receptor-C signaling and regulation [J].

Anand-Srivastava, MB .

PEPTIDES, 2005, 26 (06) :1044-1059

[6]

[Anonymous], 1915, BODILY CHANGES PAIN

[7] Human fat cell lipolysis: Biochemistry, regulation and clinical role [J].

Arner, P .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (04) :471-482

[8]

BALLANTYNE B, 1968, ARCH INT PHARMACOD T, V173, P343

[9] Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue [J].

Bamshad, M ;

Aoki, VT ;

Adkison, MG ;

Warren, WS ;

Bartness, TJ .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (01) :R291-R299

[10] Development of pseudorabies virus strains expressing red fluorescent proteins: New tools for multisynaptic labeling applications [J].

Banfield, BW ;

Kaufman, JD ;

Randall, JA ;

Pickard, GE .

JOURNAL OF VIROLOGY, 2003, 77 (18) :10106-10112

← 1 2 3 4 5 6 7 8 9 10 →