Ketamine-induced gastroprotection during endotoxemia: Role of heme-oxygenase-1

被引：28

作者：

Helmer, Kenneth S. ^{[1
]}

Suliburk, James W. ^{[1
]}

Mercer, David W. ^{[1
]}

机构：

[1] Univ Texas, Sch Med, Dept Surg, Houston, TX USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2006年 / 51卷 / 09期

关键词：

gastric injury; lipopolysacharide; mild irritants; nitric oxide synthase; heme-oxygenase; HO-1; NF-kappa B; AP-1;

D O I：

10.1007/s10620-005-9013-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inducible nitric oxide synthase contributes to lipopolysacharide-induced gastric injury. In contrast, heme-oxygenase-1 has anti-inflammatory effects and is protective against oxidative tissue injury. Ketamine attenuates injury from lipopolysacharide and is associated with changes in oxidative stress proteins, but its effects on the stomach remain to be fully elucidated. We hypothesized that ketamine would diminish gastric injury from lipopolysacharide via down-regulation of nuclear factor-kappa beta, activator protein-1, and inducible nitric oxide synthase, as well as up-regulation of heme-oxygenase-1. Ketamine up-regulated heme-oxygenase-1 and attenuated lipopolysacharide-induced changes in gastric nuclear factor-kappa beta, activator protein-1, and inducible nitric oxide synthase. Ketamine negated LPS-induced gastric injury from acidified ethanol, an effect reversed by tin protoporphorin IX. Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1.

引用

页码：1571 / 1581

页数：11