Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development

被引：8

作者：

Chafe, Shawn C. ^{[1
]}

Dedhar, Shoukat ^{[1
,2
]}

机构：

[1] BC Canc Res Ctr, Dept Integrat Oncol, Vancouver, BC, Canada

[2] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V5Z 1M9, Canada

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 12期

关键词：

breast cancer; carbonic anhydrase IX; G-CSF; hypoxia; metastasis; MDSC; pre-metastatic niche; CELLS; CANCER;

D O I：

10.1080/2162402X.2015.1048955

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary tumor-associated hypoxia stimulates the production of secreted factors that mobilize bone marrow-derived cells, including immunomodulatory myeloid-derived suppressor cells (MDSCs) to pre-metastatic niches. We recently found that the hypoxia-induced enzyme carbonic anhydrase IX (CAIX) promotes metastasis by stimulating the G-CSF dependent mobilization of granulocytic MDSCs to the lung pre-metastatic niche.

引用

页数：3

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