Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

被引:192
作者
Gautam, Nandini [1 ]
Mantha, Anil K. [2 ]
Mittal, Sunil [1 ]
机构
[1] Cent Univ Punjab, Sch Environm & Earth Sci, Ctr Environm Sci & Technol, Bathinda 151001, Punjab, India
[2] Cent Univ Punjab, Sch Basic & Appl Sci, Ctr Biosci, Bathinda 151001, Punjab, India
关键词
LEAF ESSENTIAL OIL; CELL-CYCLE ARREST; NEEM LIMONOIDS AZADIRACHTIN; PLANT ESSENTIAL OILS; NF-KAPPA-B; MULTIDRUG-RESISTANCE MDR; COLON-CANCER CELLS; TEA TREE OIL; CHEMICAL-COMPOSITION; IN-VITRO;
D O I
10.1155/2014/154106
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-kappa B and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.
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页数:23
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