A special double lumen tube for use in pigs is suitable for different lung ventilation conditions

被引:0
作者
Lesser, Thomas [1 ]
Braun, Conny [2 ]
Wolfram, Frank [1 ]
Gottschall, Reiner [3 ]
机构
[1] Jena Univ Hosp, Teaching Hosp, SRH Wald Klinikum Gera, Dept Thorac & Vasc Surg, Str Friedens 122, D-07548 Gera, Germany
[2] Jena Univ Hosp, Anim Facil & Serv, Location Dornburger Str 23a, D-07743 Jena, Germany
[3] Jena Univ Hosp, Dept Anesthesiol & Intens Care, Klinikum 1, D-07747 Jena, Germany
关键词
Double lumen tube; One-lung ventilation; One-lung flooding; Porcine; MODEL;
D O I
10.1016/j.rvsc.2020.09.007
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is required. In this study, we evaluated a new left-sided double lumen endobronchial tube designed for use in pigs under different lung ventilation conditions. Ten female pigs (weighing 35-40 kg) were transorally intubated, first with a single lumen tube and then with the left-sided double lumen tube for pigs, and mechanically ventilated. Haemodynamic and blood gas variables were recorded before and after intubation with the double lumen tube and before and after one-lung flooding of the left lung with saline solution. Each pig was repositioned (left lateral, to dorsal, to right lateral) every 30 min during one-lung flooding. Bronchoscopy and thoracic radiography were performed at fixed intervals. Blood gas variables during two-lung ventilation were not impaired by intubation with the double lumen endobronchial tube for pigs, compared with intubation with the single lumen tube. Haemodynamic and blood gas variables were not impaired by one-lung flooding. Complete flooding of the left lung was achieved for all pigs. Two-lung ventilation to reventilate the previously flooded lung provided complete air filling for all pigs. Use of this tube resulted in lung separation without obstruction of bronchi or resultant atelectasis. In this study, the new double lumen tube for pigs was safe for one-lung flooding and prevented fluid entry into the non-flooded lung.
引用
收藏
页码:111 / 116
页数:6
相关论文
共 18 条
  • [1] [Anonymous], 1982, EINFUHRUNG VERSUCHST
  • [2] Benumof JL, 1995, ANESTHESIA THORACIC
  • [3] Bikou O, 2018, METHODS MOL BIOL, V1816, P367, DOI 10.1007/978-1-4939-8597-5_29
  • [4] A novel swine model of ricin-induced acute respiratory distress syndrome
    Katalan, Shahaf
    Falach, Reut
    Rosner, Amir
    Goldvaser, Michael
    Brosh-Nissimov, Tal
    Dvir, Ayana
    Mizrachi, Avi
    Goren, Orr
    Cohen, Barak
    Gal, Yoav
    Sapoznikov, Anita
    Ehrlich, Sharon
    Sabo, Tamar
    Kronman, Chanoch
    [J]. DISEASE MODELS & MECHANISMS, 2017, 10 (02) : 173 - 183
  • [5] Role of fiberoptic bronchoscopy in conjunction with the use of double-lumen tubes for thoracic anesthesia - A prospective study
    Klein, U
    Karzai, W
    Bloos, F
    Wohlfarth, M
    Gottschall, R
    Fritz, H
    Gugel, M
    Seifert, A
    [J]. ANESTHESIOLOGY, 1998, 88 (02) : 346 - 350
  • [6] Hemodynamics and gas exchange during experimental one-lung fluid flooding in pigs
    Klinzing, S
    Lesser, T
    Schubert, H
    Bloos, F
    Klein, U
    Bartel, M
    [J]. RESEARCH IN EXPERIMENTAL MEDICINE, 1999, 199 (02) : 87 - 94
  • [7] Koch T., 1981, LEHRBUCH VETERINAR A
  • [8] Lung flooding - a new method for complete lung sonography
    Lesser, T
    Klinzing, S
    Schubert, H
    Klein, U
    Bartel, M
    [J]. RESEARCH IN EXPERIMENTAL MEDICINE, 1998, 198 (02) : 83 - 91
  • [9] Determination of the side-separated pulmonary right-to-left shunt volume
    Lesser, Thomas
    Schubert, Harald
    Klinzing, Stephan
    [J]. JOURNAL OF MEDICAL INVESTIGATION, 2008, 55 (1-2) : 44 - 50
  • [10] Lung flooding enables efficient lung sonography and tumour imaging in human ex vivo and porcine in vivo lung cancer model
    Lesser, Thomas Guenther
    Schubert, Harald
    Bischoff, Sabine
    Wolfram, Frank
    [J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2013, 18