Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is required. In this study, we evaluated a new left-sided double lumen endobronchial tube designed for use in pigs under different lung ventilation conditions. Ten female pigs (weighing 35-40 kg) were transorally intubated, first with a single lumen tube and then with the left-sided double lumen tube for pigs, and mechanically ventilated. Haemodynamic and blood gas variables were recorded before and after intubation with the double lumen tube and before and after one-lung flooding of the left lung with saline solution. Each pig was repositioned (left lateral, to dorsal, to right lateral) every 30 min during one-lung flooding. Bronchoscopy and thoracic radiography were performed at fixed intervals. Blood gas variables during two-lung ventilation were not impaired by intubation with the double lumen endobronchial tube for pigs, compared with intubation with the single lumen tube. Haemodynamic and blood gas variables were not impaired by one-lung flooding. Complete flooding of the left lung was achieved for all pigs. Two-lung ventilation to reventilate the previously flooded lung provided complete air filling for all pigs. Use of this tube resulted in lung separation without obstruction of bronchi or resultant atelectasis. In this study, the new double lumen tube for pigs was safe for one-lung flooding and prevented fluid entry into the non-flooded lung.
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Israel Inst Biol Res, Vet Ctr Preclin Res, IL-7410001 Ness Ziona, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Rosner, Amir
Goldvaser, Michael
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Israel Inst Biol Res, Dept Organ Chem, IL-7410001 Ness Ziona, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Goldvaser, Michael
Brosh-Nissimov, Tal
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Sheba Med Ctr, Infect Dis Unit, IL-5262160 Tel Hashomer, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Brosh-Nissimov, Tal
Dvir, Ayana
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Asaf Harofeh Med Ctr, Gen Intens Care Unit, IL-70300 Zerifin, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Dvir, Ayana
Mizrachi, Avi
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Kaplan Med Ctr, Gen Intens Care Unit, IL-7661041 Rehovot, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Mizrachi, Avi
Goren, Orr
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Tel Aviv Univ, Anesthesia Pain & Intens Care Div, Tel Aviv Med Ctr, IL-6093000 Tel Aviv, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Goren, Orr
Cohen, Barak
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Tel Aviv Univ, Anesthesia Pain & Intens Care Div, Tel Aviv Med Ctr, IL-6093000 Tel Aviv, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
机构:
Israel Inst Biol Res, Vet Ctr Preclin Res, IL-7410001 Ness Ziona, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Rosner, Amir
Goldvaser, Michael
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Israel Inst Biol Res, Dept Organ Chem, IL-7410001 Ness Ziona, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Goldvaser, Michael
Brosh-Nissimov, Tal
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h-index: 0
机构:
Sheba Med Ctr, Infect Dis Unit, IL-5262160 Tel Hashomer, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Brosh-Nissimov, Tal
Dvir, Ayana
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h-index: 0
机构:
Asaf Harofeh Med Ctr, Gen Intens Care Unit, IL-70300 Zerifin, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Dvir, Ayana
Mizrachi, Avi
论文数: 0引用数: 0
h-index: 0
机构:
Kaplan Med Ctr, Gen Intens Care Unit, IL-7661041 Rehovot, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Mizrachi, Avi
Goren, Orr
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Anesthesia Pain & Intens Care Div, Tel Aviv Med Ctr, IL-6093000 Tel Aviv, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel
Goren, Orr
Cohen, Barak
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h-index: 0
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Tel Aviv Univ, Anesthesia Pain & Intens Care Div, Tel Aviv Med Ctr, IL-6093000 Tel Aviv, IsraelIsrael Inst Biol Res, Dept Pharmacol, IL-7410001 Ness Ziona, Israel