Review: Remotely controlled magneto-regulation of therapeutics from magnetoelastic gel matrices

被引:56
作者
Ganguly, Sayan [1 ]
Margel, Shlomo [1 ]
机构
[1] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, Dept Chem, IL-52900 Ramat Gan, Israel
关键词
Superparamagnetic; Medical therapeutics; Polymer hydrogel; Magneto-regulative deformation; Ferrosponge; Biphasic; Drug release; IRON-OXIDE NANOPARTICLES; PULSATILE DRUG-RELEASE; ON-DEMAND DRUG; SEMI-IPN; RESPONSIVE MICROSPHERES; MAGHEMITE NANOPARTICLES; SURFACE MODIFICATION; IMAGING AGENTS; SOLID-SOLUTION; POLYMER GELS;
D O I
10.1016/j.biotechadv.2020.107611
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Surface active magnetic nanoparticles especially superparamagnetic iron oxides are already occupying a major domain in medical therapeutics. Arresting of these magnetic nanoparticles into polymer hydrogel is a spatial assembly of nanoparticles that serves the precise delivery of drug molecules. Magnetic hydrogels are very less cultured area still in the biomedical field. This review embraces how the external magnetic field (either static or oscillating) affects the payload release from the hydrogel matrix and their magneto-regulative deformation. Besides these, we also discussed how the ferrosponge and biphasic ferrogel based scaffold type systems impact over the release kinetics and tunability of drug release behaviours.
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页数:16
相关论文
共 155 条
[1]   LIPOSOMES AS IMMUNOLOGICAL ADJUVANTS [J].
ALLISON, AC ;
GREGORIADIS, G .
NATURE, 1974, 252 (5480) :252-252
[2]   Curcumin-loaded dual pH- and thermo-responsive magnetic microcarriers based on pectin maleate for drug delivery [J].
Almeida, Elizangela A. M. S. ;
Bellettini, Ismael C. ;
Garcia, Francielle P. ;
Farinacio, Maroanne T. ;
Nakamura, Celso V. ;
Rubira, Adley F. ;
Martins, Alessandro F. ;
Muniz, Edvani C. .
CARBOHYDRATE POLYMERS, 2017, 171 :259-266
[3]   Magnetic micro-device for manipulating PC12 cell migration and organization [J].
Alon, N. ;
Havdala, T. ;
Skaat, H. ;
Baranes, K. ;
Marcus, M. ;
Levy, I. ;
Margel, S. ;
Sharoni, A. ;
Shefi, O. .
LAB ON A CHIP, 2015, 15 (09) :2030-2036
[4]   Stimuli-responsive polymers and their applications in drug delivery [J].
Bawa, Priya ;
Pillay, Viness ;
Choonara, Yahya E. ;
du Toit, Lisa C. .
BIOMEDICAL MATERIALS, 2009, 4 (02)
[5]   MAGNETOTACTIC BACTERIA [J].
BLAKEMORE, R .
SCIENCE, 1975, 190 (4212) :377-379
[6]   Hydrogels for combination delivery of antineoplastic agents [J].
Bouhadir, KH ;
Alsberg, E ;
Mooney, DJ .
BIOMATERIALS, 2001, 22 (19) :2625-2633
[7]  
Bourlinos AB, 2002, CHEM MATER, V14, P3226, DOI [10.1021/cm020404l, 10.1021/cm0204041]
[8]   Liposomes as nanomedical devices [J].
Bozzuto, Giuseppina ;
Molinari, Agnese .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 :975-999
[9]   Responsive Theranostic Systems: Integration of Diagnostic Imaging Agents and Responsive Controlled Release Drug Delivery Carriers [J].
Caldorera-Moore, Mary E. ;
Liechty, William B. ;
Peppas, Nicholas A. .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :1061-1070
[10]   Enhanced Pulsatile Drug Release from Injectable Magnetic Hydrogels with Embedded Thermosensitive Microgels [J].
Campbell, Scott ;
Maitland, Danielle ;
Hoare, Todd .
ACS MACRO LETTERS, 2015, 4 (03) :312-316